RT Journal Article
SR Electronic
T1 Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease
JF BMJ Open Respiratory Research
JO BMJ Open Resp Res
FD British Thoracic Society
SP e000158
DO 10.1136/bmjresp-2016-000158
VO 4
IS 1
A1 Sumito Inoue
A1 Yoko Shibata
A1 Hiroyuki Kishi
A1 Joji Nitobe
A1 Tadateru Iwayama
A1 Yoshinori Yashiro
A1 Takako Nemoto
A1 Kento Sato
A1 Masamichi Sato
A1 Tomomi Kimura
A1 Akira Igarashi
A1 Yoshikane Tokairin
A1 Isao Kubota
YR 2017
UL http://bmjopenrespres.bmj.com/content/4/1/e000158.abstract
AB Background Low-grade exercise tolerance is associated with a poor prognosis in patients with chronic obstructive pulmonary disease (COPD). The 6 min walk test (6MWT) is commonly used to evaluate exercise tolerance in patients with COPD. However, little is known regarding the relationship between cardiac function and exercise tolerance in patients with COPD. The aim of this study was to identify predictive factors in cardiac function for low-grade exercise tolerance in patients with stable COPD.Methods We recruited 57 patients with stable COPD (men 54, women 3) to perform the 6MWT. Patients with underlying orthopaedic disease or heart failure were excluded. Cardiac function was evaluated by echocardiography and contrast-enhanced cardiac CT. We also measured pulmonary function and the 6MWT distance.Results Forced expiratory volume in 1 s (FEV1) and per cent predicted FEV, along with left ventricular end diastolic volume and left ventricular cardiac output as measured by cardiac CT, were significantly related to the 6MWT distance. On multivariate analysis, left ventricular stroke volume was the factor most closely associated with a decreased walked distance in the 6MWT.Conclusions Decreased left ventricular stroke volume was associated with low-grade exercise tolerance in patients with stable COPD without heart failure.