Table 1

Correlations of markers of lung injury and inflammation, with cardiopulmonary parameters measured in C57Bl/6 mice post IT-LPS and PBS

Lung injury marker	Arterial oxygen saturation		Breath rate		Heart rate
Lung injury marker	R²	p Value	R²	p Value	R²	p Value
Permeability index	−0.154	0.0122	−0.075	0.0916	−0.291	0.0004
RAGE expression	−0.219	0.0282	−0.002	0.8247	−0.077	0.1619
Granulocyte count	−0.108	0.0408	0.044	0.1792	−0.136	0.0150
Neutrophil count	−0.193	0.0073	0.039	0.2129	−0.094	0.0484
CXCL1/KC	−0.014	0.5118	0.042	0.2427	−0.019	0.4335
IL-6	−0.411	<0.0001	0.137	0.0285	−0.049	0.2013
MIP-2	0.036	0.2972	0.133	0.0405	<0.001	0.9737
TNFα	−0.285	0.0014	0.060	0.1696	−0.021	0.4167
VEGF	−0.065	0.1516	<−0.001	0.9176	−0.315	0.0005
IL-1β	−0.280	0.0165	0.068	0.2662	<−0.001	0.9972

Significance and R² values were calculated using a two-tailed Pearson correlation.
IL, interleukin; IT-LPS, intratracheal lipopolysaccharide; LPS; MIP-2, macrophage-inflammatory protein-2; PBS, phosphate buffered saline; RAGE, receptor for advanced glycation end; TNF α, tumor necrosis factors α; VEGF, vascular endothelial growth factor.