Comparison of baseline characteristics between patients with combined pulmonary fibrosis and emphysema (CPFE) whose 6 min walk distance decreased (worsening of 6 min walk test (6MWT)) and participants whose 6 min walk distance did not decrease (stable or improved 6MWT)
| Worsening of 6MWT (n=10) | Stable or improved 6MWT (n=5) | p Value | |
|---|---|---|---|
| Age, years | 76.2±8.7 | 75.8±5.0 | 0.927 |
| Male, n (%) | 8 (80.0) | 5 (100) | 0.524 |
| Smoking index | 1147.5±672.1 | 830.0±363.3 | 0.347 |
| Time since diagnosis, months | 52.1±41.7 | 18.2±16.2 | 0.141 |
| Body mass index, kg/m2 | 22.1±3.0 | 20.3±1.5 | 0.233 |
| MRC grade (1/2/3/4/5) | 0/0/5/5/0 | 0/0/3/2/0 | 0.573 |
| Corticosteroid therapy, n (%) | 1 (10.0) | 2 (40.0) | 0.242 |
| Home oxygen therapy, n (%) | 6 (60.0) | 2 (40.0) | 0.401 |
| Emphysema score | 10.0±3.5 | 7.6±2.3 | 0.191 |
| Pulmonary function | |||
| FVC, litres | 2.1±0.6 | 2.0±0.4 | 0.616 |
| FVC, %pred | 70.6±16.0 | 62.1±8.4 | 0.291 |
| FEV1, litres | 1.7±0.4 | 1.6±0.5 | 0.680 |
| FEV1, %predicted | 74.2±12.0 | 64.2±14.1 | 0.174 |
| FEV1/FVC, % | 83.0±10.9 | 81.4±10.0 | 0.788 |
| PASP, mm Hg | 53.2±12.5 | 39.0±10.7 | 0.075 |
| PASP >40 mm Hg, n (%) | 8 (80.0%) | 1 (20.0%) | 0.023 |
| Baseline 6 min walk test | |||
| Distance, m | 283.8±69.8 | 244.0±67.7 | 0.313 |
| SpO2 nadir, % | 82.8±9.3 | 89.8±4.3 | 0.140 |
| Borg scale | 4.5±1.4 | 2.8±1.1 | 0.031 |
| Short Form-36 | |||
| Physical function | 39.8±20.1 | 43.0±28.4 | 0.800 |
| Role-physical | 34.4±20.5 | 47.9±39.6 | 0.391 |
| Body pain | 58.3±28.0 | 67.6±34.9 | 0.585 |
| General health | 37.7±19.6 | 40.0±11.2 | 0.813 |
| Vitality | 40.0±23.0 | 37.5±23.8 | 0.848 |
| Social functioning | 57.5±34.0 | 57.5±41.1 | 1.000 |
| Role-emotional | 39.2±26.1 | 35.0±34.1 | 0.796 |
| Mental health | 61.5±18.6 | 45.0±20.0 | 0.138 |
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; MRC, Medical Research Council; PASP, pulmonary artery systolic pressure.