MUC5B promoter variant (rs35705950) genotypes and minor allele frequencies (MAF) in individuals with IPF-associated mutations
| IPF | COPD | |||||
|---|---|---|---|---|---|---|
| Mutation (n=14) | No Mutation (n=118) | Total (n=132) | Mutation (n=6) | No Mutation (n=186) | Total (n=192) | |
| G/G | 6 (43%) | 57 (48%) | 63 (48%) | 6 (100%) | 140 (75%) | 146 (76%) |
| G/T | 8 (57%) | 57 (48%) | 65 (49%) | 0 (0%) | 44 (24%) | 44 (23%) |
| T/T | 0 (0%) | 4 (3%) | 4 (3%) | 0 (0%) | 2 (1%) | 2 (1%) |
| MAF | 8 (29%)* | 65 (28%)* | 73 (28%)† | 0 (0%) | 48 (13%) | 48 (13%)† |
p Value IPF versus population (MAF 9%)=6.7 e-12; COPD versus population=0.09.12
p Value: COPD no mutation versus mutation=0.38.
*p Value IPF mutation versus no mutation=1.0.
†p Value of IPF versus COPD=1.9 e-06.
COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis.