Characteristics of healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP)
| Healthy control | IPF | HP | p Value | |
|---|---|---|---|---|
| Subjects (n) | 29 | 14 | 26 | – |
| Age (years) | 25.9±7.51 | 68.1±1.7 | 61.7±2.51 | p<0.001 |
| Sex | ||||
| Female | 12 (41.4) | 6 (42.9) | 11 (42.3) | NS |
| Male | 17 (58.6) | 8 (57.1) | 15 (57.7) | NS |
| Smoker | 0 | 7 (50.0) | 9 (34.6) | |
| Type of disease onset | ||||
| Acute | ND | 0 | 7 (26.9) | – |
| Non-acute | ND | 14 (100) | 19 (73.1) | – |
| VC (% pred) | ND | 74.9±6.98 | 82.0±4.90 | NS |
| FEV1 (% pred) | ND | 82.7±1.43 | 79.3±3.73 | NS |
| TLC (% pred) | ND | 71.9±6.89 | 67.7±12.7 | NS |
| DLco (% pred) | ND | 66.8±6.02 | 67.9±6.60 | NS |
| Total cell counts (104/mm2) | 6.64±5.7 | 9.39±1.84 | 28.5±5.54 | p<0.001 |
| Differential cell count | ||||
| Macrophage (%) | 87.5±15.1 | 78.1±5.47 | 43.8±4.26 | p<0.001 |
| Lymphocyte (%) | 7.19±4.96 | 17.5±5.53 | 52.5±1.83 | p<0.001 |
| Neutrophil (%) | 0.74±0.80 | 2.58±0.39 | 2.06±0.41 | NS |
| Eosinophil (%) | 0.24±0.36 | 2.19±0.09 | 1.34±0.63 | NS |
| CD4/8 ratio | ND | 1.87±0.06 | 2.22±0.40 | NS |
Data are shown as means±SDs. Brackets indicate percentages.
p Values were calculated by comparing patients with HP with healthy volunteers and patients with IPF by using Tukey's test.
DLco, diffusing capacity of the lungs for carbon monoxide; FEV1, forced expiratory volume in 1 s; ND, not determined; NS, no statistical significance; TLC, total lung capacity; VC, vital capacity.