CF and healthy control participant characteristics
| People with CF | Healthy controls | p Value (CF vs controls) | |
|---|---|---|---|
| N | 30 | 30 | – |
| M/F | 14/16 | 16/14 | 0.61 |
| Age (years) | 20.7 (11.1) (6–51) | 20.8 (10.7) (7–44) | 0.93 |
| FEV1 (% predicted) | 79.3 (17.9) (46.0–116.0) | 92.9 (11.3) (68.0–116.0) | 0.009 |
| FRC1/40 (L) | 1.95 (0.76) | 2.23 (1.0) | 0.22 |
| LCI1/40 (number of turnovers) | 9.0 (2.4) | 6.4 (0.5) | <0.0001 |
| LCI1/40 CV% | 5.2 (2.8) | 4.3 (2.0) | 0.16 |
| LCI1/40 triplicate test duration (min) | 21.8 (9.7) (8.0–57.1) | 19.4 (6.5) (10.1–31.1) | 0.26 |
| FRC1/30 (L) | 1.93 (0.76) | 2.24 (1.02) | 0.18 |
| LCI1/30 (number of turnovers) | 7.7 (1.6) | 5.9 (0.4) | <0.0001 |
| LCI1/30 CV% | 4.6 (3.2) | 4.1 (2.8) | 0.53 |
| LCI1/30 triplicate test duration (min) | 20.9 (9.1) (7.3–53.2) | 18.9 (6.2) (9.9–29.9) | 0.34 |
| FRC1/20 (L) | 1.90 (0.75) | 2.24 (1.0) | 0.15 |
| LCI1/20 (number of turnovers) | 6.6 (1.2) | 5.2 (0.4) | <0.0001 |
| LCI1/20 CV% | 5.7 (3.4) | 4.6 (2.3) | 0.14 |
| LCI1/20 triplicate test duration (min) | 20.0 (8.9) (6.7–51.7) | 18.3 5.9 (9.6–28.3) | 0.38 |
| FRC1/10 (L) | 1.84 (0.73) | 2.22 (1.00) | 0.09 |
| LCI1/10 (number of turnovers) | 4.7 (0.6) | 4.0 (0.3) | <0.0001 |
| LCI1/10 CV% | 5.4 (3.8) | 4.3 (2.8) | 0.25 |
| LCI1/10 triplicate test duration (min) | 18.6 (8.1) (5.7–46.9) | 17.1 (5.5) (8.8–26.6) | 0.41 |
All values summarised as mean (SD)±(range).
CF, cystic fibrosis; CV, coefficient of variation, F, female; FEV1, forced expiratory volume in 1 s; FRC, functional residual capacity; LCI, Lung Clearance Index; M, male.