Risk factors associated with mortality in patients with pulmonary aspergillosis
| Dead, n=14 | Alive, n=55 | p Value | |
|---|---|---|---|
| Age (years) | |||
| <35 | 2 (14.3) | 18 (32.7) | 0.31 |
| 35–45 | 3 (21.4) | 13 (23.6) | |
| >45 | 9 (64.3) | 24 (43.6) | |
| Gender | |||
| Male | 8 (57.1) | 40 (72.7) | 0.25 |
| Female | 6 (42.9) | 15 (27.3) | |
| Smoking status | |||
| Current | 2 (16.7) | 0 | 0.004 |
| Ex-smoker | 1 (8.3) | 18 (34.6) | |
| Non-smoker | 9 (75) | 34 (65.4) | |
| Renal failure | 8 (57.14) | 8 (14.54) | 0.002 |
| DM | 8 (57.1) | 14 (25.5) | 0.05 |
| Steroids use | 3 (21.4) | 12 (21.8) | 0.64 |
| Chemotherapy | 2 (14.28) | 3 (5.4) | 0.26 |
| Haematological malignancies | 5 (35.7) | 5 (9.1) | 0.01 |
| Past TB | 2 (14.2) | 25 (45.45) | 0.22 |
| Active TB | 2 (14.2) | 7 (12.7) | 0.58 |
| COPD | 0 | 7 (12.7) | 0.18 |
| Asthma | 2 (14.28) | 5 (9.09) | 0.43 |
| Nodular infiltrates | 9 (64.28) | 20 (36.36) | 0.29 |
| Consolidation | 11 (78.57) | 8 (14.54) | 0.001 |
| Bronchiectasis | 1 (7.14) | 9 (16.36) | 0.24 |
| Fungal ball | 3 (21.4) | 22 (40.0) | 0.11 |
| Respiratory complications | 11 (78.6) | 17 (30.9) | 0.002 |
| Length of hospital stay (mean days) | 16.2±10.4 | 9.1±8.2 | 0.009 |
| Pneumothorax | 3 (21.4%) | 7 (12.72%) | 0.32 |
| ICU stay | 13 (92.85%) | 5 (9.09%) | 0.001 |
| Mechanical ventilation | 14 (100%) | 3 (5.45%) | 0.001 |
| NIMV use | 1 (7.14%) | 7 (12.72%) | 0.48 |
| Surgical resection | 1 (7.1) | 27 (49.1) | 0.001 |
| Independent factors associated with mortality on multivariate analysis | |||
| Factors | OR ( 95% CI) | p Value | |
| Hypoxic respiratory failure | 6.80 (1.46 to 31.60) | 0.01 | |
| DM | 6.91 (1.46 to 32.54) | 0.01 | |
| Length of hospital stay (mean days) | 1.08 (1.007 to 1.15) | 0.03 | |
DM, diabetes mellitus; ICU, intensive care unit; NIMV, non-invasive mechanical ventilation; TB, tuberculosis.