LCI and spirometry before and 90 mins after treatment
| HTS before ACT (n=13) | HTS during ACT (n=13) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Post | MD (95% CI) | Rx effect | p value | Baseline | Post | MD (95% CI) | Rx effect | p value | |
| Mean (SD) LCI (no. turnovers) | 14.1 (3.6) | 14.2 (3.6) | 0.10 (−0.59 to 0.79) | 0.06 | 0.75 | 13.8 (3.4) | 13.9 (3.6) | 0.12 (−0.42 to 0.66) | 0.14 | 0.49 |
| Mean (SD) FRC (L) | 2.24 (0.5) | 2.18 (0.5) | −0.55 (−0.17 to 0.06) | 0.22 | 0.27 | 2.20 (0.5) | 2.09 (0.5) | −0.11 (0.20 to 0.03) | 0.40 | 0.04* |
| Mean (SD) FEV1% predicted | 47.2 (18.9) | 48.6 (18.3) | 1.38 (−0.61 to 3.38) | 0.38 | 0.05 | 47.2 (18.2) | 48.8 (19.4) | 1.64 (−1.06 to 4.34) | 0.29 | 0.14 |
| Mean (SD) FEF25–75% predicted | 25.2 (27.5) | 26.8 (26.9) | 1.54 (−1.41 to 4.48) | 0.26 | 0.18 | 23.9 (25.6) | 27.4 (25.4) | 3.46 (−2.80 to 9.72) | 0.31 | 0.11 |
*p<0.05.
ACT, airway clearance treatment; FEF25–75% predicted, forced expiratory flow 25–75; FEV1% predicted, forced expiratory volume in 1 s; FRC, functional residual capacity; HTS, hypertonic saline; LCI, Lung Clearance Index.