Study 1: patient characteristics for whole group and separated by ACE genotype
| All n=168 | DD n=48 (28%) | ID n=91 (53%) | II n=29 (19%) | |
|---|---|---|---|---|
| Age | 68.7 (9.0) | 69.2 (10.4) | 67.8 (8.8) | 71.0 (6.9) |
| Gender (n(%) female) | 92 (54.8) | 23 (47.9) | 52 (57.1) | 15 (51.7) |
| FEV1 (% predicted) | 51.9 (22.7) | 50.4 (22.3) | 52.8 (24.4) | 50.1 (18.7) |
| FEV1/FVC (%) | 48.1 (17.6) | 48.0 (17.7) | 48.7 (19.3) | 46.2 (13.2) |
| ISWD baseline (m) | 251.4 (149.8) | 261.7 (184.0) | 253.0 (140.2) | 223.4 (103.9) |
| ISWD end (m) | 318.9 (170.6) | 331.0 (200.0) | 313.6 (165.3) | 301.7 (109.4) |
| ΔISWD (m) | 67.5 (74.7) | 69.4 (66.6) | 60.6 (76.2) | 78.3 (78.2) |
| ΔISWD (%) | 43.3 (66.7) | 45.6 (76.9) | 36.0 (53.2) | 59.2 (84.5) |
Values are mean (SD). All p>0.05 ANOVA across genotypes.
FEV1, forced expiratory volume in one second; FVC, forced vital capacity; ISWD, incremental shuttle walk test distance.