Unadjusted analyses of the association between rapid decline in lung function as the predictor variable (between Coronary Artery Risk Development in Young Adults (CARDIA) Y20 and peak determined from the highest value at Y0, Y2, Y5 and Y10 visits) and incident, prevalent and persistent excess urinary albumin excretion (eUAE) as outcome variables (latter measured at Y20 and/or Y25 examination visits at a mean age of 45 and/or 50 years))
| Categories of lung function decline | Incident eUAE | Prevalent eUAE | Persistent eUAE | |||
| Frequency (%) | p Value | Frequency (%) | p Value | Frequency (%) | p Value | |
| FEV1 decline | ||||||
| Rapid FEV1 decline ≥52 mL/year | 4.0% (n=34/844) | 0.006 | 10.5% (n=107/1019) | 0.006 | 6.6% (n=68/878) | <0.001 |
| Non-rapid FEV1 decline <52 mL/year | 2.0% (n=35/1714) | 7.5% (n=152/2033) | 3.4% (n=61/1773) | |||
| FVC decline | ||||||
| Rapid FVC decline ≥45.8 mL/year | 4.3% (n=36/835) | <0.001 | 11.5% (n=116/1006) | <0.001 | 7.1% (n=61/863) | <0.001 |
| Non-rapid FVC decline <45.8 mL/year | 1.9% (n=33/1723) | 7.0% (n=143/2046) | 3.3% (n=58/1786) | |||
Rapid decline, defined by the highest tertile of decline, was compared with the lower two tertiles. Rapid FEV1 decline was defined by ≥52 mL/year. Rapid FVC decline was defined by ≥45.8 mL/year.
Incident eUAE was defined as the new occurrence of excretion at Y20 or Y25 examination visits (at a mean age of 45 or 50 years) without antecedent excretion. Prevalent eUAE was defined as excretion at CARDIA Y20 and/or Y25, irrespective of antecedent excretion. Persistent eUAE was defined as excretion at Y25 plus at one or more measurements at Y10, Y15 or Y20.
Similar significant associations were found when studying lung function decline as a continuous predictor variable (online supplementary table E-I). Association of urinary albumin creatinine ratio on lung function decline, both studied as continuous variables, showed significant association with FVC, as shown in online supplementary table E-II.