Table 1

SNPs associated with iron and iron biomarkers in a published genome-wide association meta-analysis24

SNPsRisk allele*Nearest gene(s)Effect estimates reported†
IronFerritinTransferrinTransferrin saturation
rs1799945‡CHFE−0.189−0.0650.114−0.231
rs1800562§GHFE−0.328−0.2040.479−0.577
rs855791§ATMPRSS6−0.181−0.0550.044−0.190
rs8177240†T/G¶TF−0.0660.380−0.100
rs7385804‡CTFR2−0.064−0.054
rs744653§TWDR75SLC40A1−0.0890.068
rs651007‡TABO−0.050
rs411988‡ATEX14−0.044
rs9990333§CTFRC0.051
rs4921915‡ANAT20.079
rs6486121§CARNTL0.046
rs174577‡AFADS20.062
  • *Associated with lower iron status, lower ferritin status, higher transferrin status or lower transferrin saturation status with p<5.10−8.

  • †From meta-analysis of covariate-adjusted standardised regression coefficients of phenotypic values on the allele count for the risk allele.

  • ‡Imputed SNP.

  • §Genotyped SNP.

  • ¶T is the risk allele for iron (associated with lower iron status) and G is the risk allele for transferrin and transferrin saturation (associated with higher transferrin status and lower transferrin saturation status).

  • SNP, single nucleotide polymorphism.