Associations between maternal genotypic scores and atopy, asthma, FEV1, FVC and FEF25-75 in the offspring
| OR or β*† (95% CI) | ||||
| Iron score | Ferritin score | Transferrin score | Transferrin saturation score | |
| Atopy (n=3943) | ||||
| Per SD increase | 1.02 (0.95 to 1.10) | 1.00 (0.92 to 1.08) | 0.97 (0.90 to 1.04) | 1.00 (0.93 to 1.08) |
| P for trend | 0.60 | 0.93 | 0.38 | 0.96 |
| Asthma (n=4873) | ||||
| Per SD increase | 1.05 (0.96 to 1.14) | 0.97 (0.89 to 1.06) | 0.97 (0.89 to 1.05) | 1.03 (0.94 to 1.12) |
| P for trend | 0.31 | 0.54 | 0.47 | 0.56 |
| FEV1 (n=4014) | ||||
| Per SD increase | −0.02 (−0.05 to 0.01) | −0.01 (−0.04 to 0.02) | −0.01 (−0.05 to 0.02) | −0.02 (−0.05 to 0.01) |
| P for trend | 0.26 | 0.48 | 0.34 | 0.14 |
| FVC (n=4086) | ||||
| Per SD increase | 0.00 (−0.03 to 0.03) | 0.01 (−0.03 to 0.04) | −0.01 (−0.04 to 0.02) | −0.01 (−0.04 to 0.02) |
| P for trend | 0.79 | 0.75 | 0.42 | 0.44 |
| FEF25-75 (n=4086) | ||||
| Per SD increase | −0.02 (−0.05 to 0.01) | −0.02 (−0.06 to 0.01) | −0.02 (−0.05 to 0.01) | −0.02 (−0.06 to 0.01) |
| P for trend | 0.19 | 0.13 | 0.27 | 0.13 |
*OR for asthma and atopy; difference in age, height and gender-adjusted SD units (β) for FEV1, FVC and FEF25-75.
†Adjusted for iron supplementation during pregnancy and population substructure.
FEF25-75, maximal mid-expiratory flow; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.