Original ArticlesEffects of ischemia on pulmonary dysfunction after cardiopulmonary bypass
Section snippets
Material and methods
Twenty neonatal piglets (1 week old, 2.5 to 3.1 kg) were randomly assigned to two separate groups. All animals received humane care in accordance with the “Guide for the Care and Use of Laboratory Animals” published by the National Institutes of Health (NIH publication 85-23, revised 1985) and as approved by the Duke University Animal Care and Use Committee.
Anesthesia was induced in all piglets with intramuscular ketamine (20 mg/kg) and acepromazine (1 mg/kg). The piglets were intubated and
Arterial blood gases and hemodynamic data
There were no significant differences in the arterial blood gases between the two groups. Left atrial pressures were maintained at 3 to 7 mm Hg with volume infusions and were not significantly different between the two groups. Fluid requirements for each group were not significantly different. Results are summarized in Table 1.
Pulmonary vascular resistance
Pulmonary vascular resistance increased significantly after 90 minutes of CPB in all groups compared with baseline values (p < 0.005). There was no significant
Comment
In this study, CPB resulted in lung injury in both the full and partial CPB groups as evidenced by increased PVR, increased A–a O2 gradients, and decreased pulmonary compliance. This supports previous studies indicating that exposure to CPB can cause pulmonary injury 6, 7, 8. When the full and partial CPB groups were compared with each other, there was a greater degree of injury present in the full CPB group, suggesting that cessation of pulmonary arterial flow is an important factor in the
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