Cytotoxicity of human eosinophil granule major basic protein to human nasal sinus mucosa in vitro*
References (30)
- et al.
Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma
Lancet
(1982) - et al.
A clinical and pathologic study of chronic sinusitis: the role of the eosinophil
J Allergy Clin Immunol
(1988) - et al.
The eosinophilic leukocyte: structure and function
Adv Immunol
(1986) The eosinophil and bronchial asthma: current understanding
J Allergy Clin Immunol
(1990)- et al.
The eosinophil and the pathophysiology of asthma
J Allergy Clin Immunol
(1986) - et al.
Increased biosynthesis of platelet-activating factor in activated human eosinophils
J Biol Chem
(1984) - et al.
The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity
J Allergy Clin Immunol
(1988) Asthma as an axon reflex
Lancet
(1986)- et al.
Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium
Lab Invest
(1980) - et al.
Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma
Mayo Clin Proc
(1981)
Charcot-Leyden crystal protein and eosinophil granule major basic protein in sputum of patients with respiratory diseases
Am Rev Respir Dis
The effect of purified human eosinophil major basic protein on mammalian ciliary activity
Am Rev Respir Dis
Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils
J Clin Invest
Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin
J Immunol
Damage to schistosomula of Schistoma mansoni induced directly by eosinophil major basic protein
J Immunol
Cited by (99)
A new experimental model to study shrimp allergy
2023, Immunology LettersEmerging Roles for Eosinophils in the Tumor Microenvironment
2016, Trends in CancerCitation Excerpt :Eosinophils can exert potent cytotoxic activities (Figure 3) and subsequently mediate tissue damage through secretion of several unique proteins that are stored in their secondary granules, for example, major basic protein (MBP; type I and II), eosinophil peroxidase, eosinophil cationic protein, and eosinophil-derived neurotoxin [63]. By disrupting the integrity of lipid bilayers, MBP is cytotoxic to helminths, tumor cells, and mammalian cells (e.g., respiratory epithelial cells) [14,64–67]. Eosinophil peroxidase can catalyze the oxidation of nitric oxide and halides to promote oxidative stress (via reactive oxygen and nitrogen species), consequently leading to cell death [68].
Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma
2015, Journal of Allergy and Clinical ImmunologyChanging roles of eosinophils in health and disease
2014, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :The cloning and characterization of these genes showed an interesting and provocative commonality: the secondary granule proteins generally were very cationic (explaining the propensity of the secondary granules to bind the acidic aniline dye eosin), they possessed in some cases robust enzymatic activities (eg, ribonuclease and peroxidase activities), and in general were cell cytocidal (reviewed by Ackerman et al8). Specifically, upon exposure in cell culture settings11,18 or tissue/organ ex plant cultures,19,22 the unique enzymatic activities and/or biochemistry that surround these proteins elicited cell death. This phenomenon also extended to multicellular parasites that died after exposure to physiologically relevant levels of several eosinophil granule proteins.16,17,23,24
Risk factors for olfactory dysfunction in chronic rhinosinusitis
2013, Auris Nasus LarynxCitation Excerpt :These findings suggest that eosinophils may act as important effectors of olfaction. Eosinophilia is a hallmark of nasal polyps, is thought to be a risk factor for disease recurrence [7,8], and is thought to play a major role in the pathogenesis of CRS [23,24]. Patients with CRS who have high infiltration of activated eosinophils, i.e., ECRS, significantly had severe olfactory dysfunction [25].
The Influence of Upper Airway Disease on the Lower Airway
2012, Kendig and Chernick's Disorders of the Respiratory Tract in Children
- *
Supported in part by National Institutes of Health Grants AI 09728 and AI 15231, and from the Mayo Foundation.
- *
From the Department of Otorhinolaryngology, Yamanashi College of Medicine, Tamaho, Japan
- **
From the Departments of Immunology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn.
- ***
From the Department of Otorhinolaryngology, Nihon University School of Medicine, Tokyo, Japan.