The common cold: Effects of intranasal fluticasone propionate treatment☆,☆☆,★,★★
Section snippets
Volunteers
Two hundred young adults were enrolled in the study. The study period was from November 1994 to November 1995, excluding the summer months (June, July, and August 1995). Subjects were recruited through advertisements in local newspapers, through posters in student canteens, and by contact persons. All subjects were of the white race. The mean age (± SD) of male subjects (n = 59) was 24.0 years (± 2.7 years), and that of female subjects (n = 141) was 24.1 years (± 3.6 years). An entry criterion
Subjects
There were no significant differences in the demographic characteristics between the two treatment groups on day 1. One hundred ninety-nine subjects (99.5%) completed the study according to the protocol. One patient (in the placebo group) was excluded on day 7 because of improper use of study medication. On day 21, 63% of the subjects were asymptomatic. No patients had symptoms requiring an additional follow-up visit after day 21.
Effects of the FP treatment
No differences were seen in the frequency of symptoms between the
DISCUSSION
Several recent studies have shown some relief of symptoms in the common cold with ipratropium bromide, first-generation antihistamines, and combined interferon-antimediator therapy. 12 Two previous studies investigated the efficacy of corticosteroids in the treatment of the common cold. The placebo-controlled study of Farr et al.13 examined the efficacy of a combination of intranasal beclomethasone and oral prednisone in experimental rhinovirus infection. Beclomethasone was started 4 days
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Cited by (0)
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From the Departments of aPediatrics, bPulmonary Diseases, and Clinical Allergology, University of Turku, Turku; cthe Department of Pediatrics, University of Oulu, Oulu; and dGlaxoWellcome Ltd.
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Supported by the Academy of Finland, GlaxoWellcome Ltd., the Sigrid Juselius Foundation, and the Turku University Foundation.
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Reprint requests: Tuomo Puhakka, MD, Research Unit, Department of Pediatrics, Vähä Hämeenkatu 1 A 3, 20500 Turku, Finland.
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