ANGIOTENSIN-CONVERTING ENZYME AND THE COUGH REFLEX
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Chronic cough, a major challenge for clinicians
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2022, Pharmacology and TherapeuticsCitation Excerpt :ACE metabolises several small peptides, activating bradykinin, but metabolising SP. In 1987, this latter effect was hypothesised as the mechanism of ACE inhibitor cough due to the increased synaptic levels of SP (Morice, Brown, Lowry, & Higenbottam, 1987). The role of SP in the regulation of the cough reflex has been demonstrated centrally in the nTS, with microinjection of this neuropeptide into this region causing upregulation of cough responses. (
Effect of prolonged mechanical ventilation on cough function and TRPV1 expression
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2021, Journal of Allergy and Clinical Immunology: In PracticeQuantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings
2019, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Participants were identified by self-report to be healthy. Participants were excluded if they had a self-reported history of a neurogenic disorder; clinically significant; respiratory disease (e.g. asthma, COPD, chronic bronchitis, emphysema); gastro-esophageal reflux; taking ACE inhibitor or codeine-based drugs; were self-reported current, or previous smokers; or had a recent (<2 weeks) acute upper respiratory tract infection (URTI), as these are factors that are known to influence cough sensitivity [7,21–23]. No participants had prior experience of citric acid cough reflex testing.