Chest
Clinical InvestigationsSmoking Cessation Rapidly Reduces Cell Recovery in Bronchoalveolar Lavage Fluid, While Alveolar Macrophage Fluorescence Remains High
Section snippets
Subjects
Eighteen apparently healthy smokers (mean age, 41.4 years; range, 27 to 61 years; 17 women, 1 man) were included in the study. The majority of the participants were treated with hypnosis at the Stockholm Anti Smoking Clinic during the study. Their mean (±SD) cigarette consumption was 22.6 ±7.8 pack-years and the consumption exceeded 15 cigarettes per day for the last ten years. Eight subjects participated in all six lavages (Table 1), whereas the others were excluded from the study at different
Endobronchial Findings
Signs of bronchitis (edema, erythema, and increased amounts of mucus) were observed macroscopically at the first investigation. After smoking cessation of three months, however, there was a less pronounced bronchitis, and after six months, the bronchial mucosa looked normal.
General Lavage Data
The median recovery of the instilled fluid was more than 60 percent at all lavage occasions (Table 2). There was a significantly higher recovery after smoking had ceased compared with the recovery at lavages done when the
DISCUSSION
In this study, we investigated the effect of smoking cessation on the cellular components in the BAL fluid by performing consecutive BALs on healthy smokers before and at different points of time after smoking had stopped. Furthermore, the decline of fluorescence in the AMs was followed with a flow cytofluorometric technique.
As the interval between the first and the second lavage was short, the findings in the second lavage could have been influenced by the previous lavage. To minimize such an
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This study was supported by grants from the Swedish Medical Research Council (grant 16 X - 105) and the Swedish Heart-Lung Foundation.
Manuscript received May 9; revision accepted August 7.