Chest
Clinical Investigations: TumorsTypical and Atypical Pulmonary Carcinoids: Outcome in Patients Presenting With Regional Lymph Node Involvement
Section snippets
Materials and Methods
A computerized search of the medical records at the Mayo Clinic from 1976 to 1997 revealed 517 patients with pulmonary carcinoid tumors, from which we identified 36 patients with pulmonary carcinoid tumors involving regional thoracic lymph nodes but without distant disease. The medical records of these 36 patients were reviewed, and the study population included only patients with pulmonary carcinoid tumors presenting with thoracic lymph node metastases at the time of surgical resection. This
Results
Thirty-six patients with pulmonary carcinoid tumors had thoracic lymph node involvement at the time of surgical resection and staging from 1976 to 1997. These included 15 men and 21 women with a mean age of 55.9 years (age range, 17 to 77 years). The original classification was 24 typical carcinoid tumors and 12 atypical carcinoid tumors (Table 3). Using the current criteria for classifying pulmonary neuroendocrine tumors, four patients originally receiving diagnoses of typical carcinoid tumors
Discussion
Pulmonary carcinoid tumors comprise 1 to 2% of all lung malignancies.1,15,23 Historically called bronchial adenomas, they were thought to be benign tumors. The recognition of a more aggressive variety of carcinoid tumor, the atypical carcinoid, suggested that they might all be malignant.4,5,11,18,20 Currently, typical and atypical carcinoids are considered to be part of a spectrum of malignant neoplasms with neuroendocrine differentiation along with large cell neuroendocrine carcinoma and small
ACKNOWLEDGMENT
We thank Darrell R. Schroeder from the Mayo Clinic Section of Biostatistics for performing the statistical analysis in this study.
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