Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
Relationship between Habit of Cigarette Smoking and Airflow Limitation in Healthy Japanese Individuals: The Takahata Study
Daisuke Osaka, Yoko Shibata, Shuichi Abe, Sumito Inoue, Yoshikane Tokairin, Akira Igarashi, Keiko Yamauchi, Tomomi Kimura, Michiko Sato, Hiroyuki Kishi, Noriaki Takabatake, Makoto Sata, Tetsu Watanabe, Tsuneo Konta, Sumio Kawata, Takeo Kato, Isao Kubota
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Keywords: pulmonary function test, airflow limitation, COPD, cigarette smoking, FEV1, community-based health check-up, epidemiology
JOURNAL OPEN ACCESS

2010 Volume 49 Issue 15 Pages 1489-1499

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Abstract

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation. The prevalence of airflow limitation in Japan is 10.9% (16.4% of males and 5.0% of females). Cigarette smoking is well known as a major cause of COPD. However, few epidemiological studies have evaluated the effects of cigarette smoking on pulmonary function in healthy subjects.
Methods Subjects aged 40 years or older (n=2,917), who had participated in a community-based annual health check in Takahata, Japan, from 2004 through 2005, were enrolled in the study. The smoking histories of these subjects were investigated using a self-reported questionnaire. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and forced expiratory flow at 25-75% of FVC (FEF25-75) were measured by standard procedures using spirometric machines.
Results There were 554 current smokers (18.6%) and 403 former smokers (13.8%). The prevalence of airflow limitation defined by FEV1/FVC <0.7 in this population was 10.6%, and prevalence of airflow limitation defined by 5th percentile lower limit of normal was 6.4%. In smokers, percent predicted values of measured spirometric parameters (%FVC, %FEV1 and %FEF25-75) decreased significantly with age, except for male %FVC. Also, percent predicted values of measured spirometric parameters decreased significantly with increasing pack-years, except for female %FEF25-75.
Conclusion Cigarette smoking increased the prevalence and severity of airflow limitation. It is concluded that cigarette smoking increases the risk of airflow limitation in a healthy Japanese population.

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© 2010 by The Japanese Society of Internal Medicine
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