Tracheobronchopulmonary carcinoid tumors: analysis of 40 patients

Ann Thorac Cardiovasc Surg. 2011;17(1):7-12. doi: 10.5761/atcs.oa.08.01309.

Abstract

Introduction: Carcinoid tumors are a type of neuroendocrine tumors which usually involve the upper airways and the patients most often complain of cough and hemoptysis.

Materials and methods: This study was performed from 1990 through 2007 on 40 patients with carcinoid tumor who had been followed up for at least 3 years. The statistical analysis were based on tumor epidemiology, treatment and the 3-year survival. The factors influencing the survival were analyzed using SPSS and exact Fisher test.

Results: M/F was 16/24 with mean age 34 years. Their most common symptoms were coughing (90%) . The left main bronchus was the most common site of involvement (25%). 95% of all the cases underwent surgery and 5% of the patients underwent chemoradiotherapy due to distant metastasis . The most common surgical procedure was lobectomy or biloectomy (57.8%). Bronchial sleeve resection was performed on 10.4% of the patients. The most common pathology was the typical form (90%) and 5% of the madiastinal lymph nodes were involvd all of the atypical type. Carcinoid syndrome was seen in one patient (2.5%) and post operative adjuvant treatment was done in 5% of the patients after surgery because of mediastinal lymph node involvement. Post operative recurrence occurred in one patient (2.6%) of the atypical form with mediastinal lymph nodes involvement. The most common complication of surgery was a long- term air leakage (10.4%) and the surgical death rate was 0%. 3-year survival was 92.5%. The factors influencing the survival included the pathological type, distant metastasis and mediastinal lymph node involvement.

Conclusion: Carcinoid tumors have mostly been responsive to surgical intervention, resulting in a long term survival.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bronchial Neoplasms / complications
  • Bronchial Neoplasms / mortality
  • Bronchial Neoplasms / pathology
  • Bronchial Neoplasms / surgery*
  • Carcinoid Tumor / complications
  • Carcinoid Tumor / mortality
  • Carcinoid Tumor / secondary
  • Carcinoid Tumor / surgery*
  • Chemotherapy, Adjuvant
  • Child
  • Cough / etiology
  • Dyspnea / etiology
  • Female
  • Hemoptysis / etiology
  • Humans
  • Iran / epidemiology
  • Kaplan-Meier Estimate
  • Lung Neoplasms / complications
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / surgery*
  • Lymph Node Excision
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Pneumonectomy
  • Radiotherapy, Adjuvant
  • Respiratory Sounds / etiology
  • Risk Assessment
  • Risk Factors
  • Survival Rate
  • Thoracic Surgical Procedures* / adverse effects
  • Thoracic Surgical Procedures* / mortality
  • Time Factors
  • Tracheal Neoplasms / complications
  • Tracheal Neoplasms / mortality
  • Tracheal Neoplasms / pathology
  • Tracheal Neoplasms / surgery*
  • Treatment Outcome
  • Young Adult