The assessment of endothelial function: from research into clinical practice

AJ Flammer, T Anderson, DS Celermajer, MA Creager… - Circulation, 2012 - Am Heart Assoc
The discovery of nitric oxide (NO) as a crucial endothe-lium-derived molecule for vascular
relaxation and the recognition of the endothelium as more than a passive interface between …

The Mediterranean diet, its components, and cardiovascular disease

RJ Widmer, AJ Flammer, LO Lerman… - The American journal of …, 2015 - Elsevier
One of the best-studied diets for cardiovascular health is the Mediterranean diet. This
consists of fish, monounsaturated fats from olive oil, fruits, vegetables, whole grains …

Cocoa and cardiovascular health

R Corti, AJ Flammer, NK Hollenberg, TF Lüscher - Circulation, 2009 - Am Heart Assoc
Epidemiological data demonstrate that regular dietary intake of plant-derived foods and
beverages reduces the risk of coronary heart disease and stroke. Among many ingredients …

Endothelial cell infection and endotheliitis in COVID-19

Z Varga, AJ Flammer, P Steiger, M Haberecker… - The Lancet, 2020 - thelancet.com
Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease
2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the …

The eye and the heart

J Flammer, K Konieczka, RM Bruno… - European heart …, 2013 - academic.oup.com
The vasculature of the eye and the heart share several common characteristics. The easily
accessible vessels of the eye are therefore—to some extent—a window to the heart. There is …

Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure …

VP Harjola, W Mullens, M Banaszewski… - European journal of …, 2017 - Wiley Online Library
Organ injury and impairment are commonly observed in patients with acute heart failure
(AHF), and congestion is an essential pathophysiological mechanism of impaired organ …

Endothelial dysfunction over the course of coronary artery disease

E Gutierrez, AJ Flammer, LO Lerman… - European heart …, 2013 - academic.oup.com
The vascular endothelium regulates blood flow in response to physiological needs.
Endothelial dysfunction is closely related to atherosclerosis and its risk factors, and it …

[HTML][HTML] The primary vascular dysregulation syndrome: implications for eye diseases

J Flammer, K Konieczka, AJ Flammer - EPMA Journal, 2013 - Springer
Vascular dysregulation refers to the regulation of blood flow that is not adapted to the needs
of the respective tissue. We distinguish primary vascular dysregulation (PVD, formerly called …

Dark chocolate improves coronary vasomotion and reduces platelet reactivity

AJ Flammer, F Hermann, I Sudano, L Spieker… - Circulation, 2007 - Am Heart Assoc
Background—Dark chocolate has potent antioxidant properties. Coronary atherosclerosis is
promoted by impaired endothelial function and increased platelet activation. Traditional risk …

[HTML][HTML] Endothelial dysfunction in COVID-19: Current findings and therapeutic implications

MP Nägele, B Haubner, FC Tanner, F Ruschitzka… - Atherosclerosis, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) increases the risk of several non-pulmonary
complications such as acute myocardial injury, renal failure or thromboembolic events. A …