Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab …

Refer all patients with a chest X-ray suggestive of MPM urgently (via the 2-week wait
suspected cancer pathway in England and Wales). Consider referral for further investigation …

Objective: Sublobar resections may offer a method of increasing resection rates in patients
with lung cancer and poor lung function, but are thought to increase recurrence and …

Abstract Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20–50 years after
exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate …

Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos
exposure. The molecular mechanisms underlying the long latency period of mesothelioma …

Introduction Cytoreductive surgery has been used a part of multimodality treatment in
patients with malignant pleural mesothelioma (MPM). The residual microscopic disease that …

Objective: The use of VATS metastasectomy remains controversial because of doubt
surrounding its ability to remove palpable but CT occult lesions. We aim to evaluate our …