First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …

The AMP-activated protein kinase is a sensor of cellular energy status that is found in all
eukaryotic cells. It is activated by rising AMP and falling ATP by a complex mechanism that …

Background Patients from ethnic minority groups are disproportionately affected by
Coronavirus disease (COVID-19). We performed a systematic review and meta-analysis to …

On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B. 1.1.
529 was announced, containing far more mutations in Spike (S) than previously reported …

Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection …

The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both
the cellular and whole-body levels. Two upstream kinases have been reported to activate …

Purpose To establish evidence of activity, or lack thereof, of cetuximab-based therapy in
patients with refractory colorectal cancer with tumors that do not demonstrate epidermal …

Graphene-based materials are promising building blocks for future nanodevices owing to
their superior electronic, thermal, and mechanical properties as well as their chemical …

In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG)
correlate with reduced skeletal muscle and whole body insulin action. The aim of this study …

Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical
benefits, but only a fraction of patients respond to treatment. To predict ICB response, we …