Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction

T Shishido, N Nozaki, S Yamaguchi, Y Shibata… - Circulation, 2003 - Am Heart Assoc
Background—Toll-like receptors (TLRs) are members of the interleukin-1 receptor family
and transduce similar signals as interleukin-1 receptor in response to exogenous …

High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure

Y Koyama, Y Takeishi, T Arimoto, T Niizeki… - Journal of cardiac …, 2007 - Elsevier
BACKGROUND: Pentosidine, one of the advanced glycation end products (AGE), is
generated by nonenzymatic glycation and oxidation of proteins. The receptor of AGE …

Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes

J Nitobe, S Yamaguchi, M Okuyama… - Cardiovascular …, 2003 - academic.oup.com
Abstract Objective: Fas ligand (FasL) is a key cytokine which initiates apoptosis when FasL
binds to its receptor, Fas. Cardiac myocytes are generally resistant to Fas-induced …

Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients

T Niizeki, Y Takeishi, T Arimoto, N Takabatake… - Journal of cardiac …, 2007 - Elsevier
BACKGROUND: Heart-type fatty acid-binding protein (H-FABP) is a small cytosolic protein
and released into the circulation when the myocardium is injured. Previous studies have …

Serum resistin is associated with high risk in patients with congestive heart failure a novel link between metabolic signals and heart failure

Y Takeishi, T Niizeki, T Arimoto, N Nozaki… - Circulation …, 2007 - jstage.jst.go.jp
Background Resistin is derived from fat tissue in rodents, and serum levels are elevated in
animal models of obesity and insulin resistance. Recent studies have reported that resistin is …

Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure

T Arimoto, Y Takeishi, R Shiga, A Fukui… - Journal of cardiac …, 2005 - Elsevier
BACKGROUND: Heart-type fatty acid binding protein (H-FABP) is released into the
circulation when the myocardium is injured and is a novel marker for the diagnosis of acute …

Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure

T Niizeki, Y Takeishi, T Arimoto, N Nozaki… - Circulation …, 2008 - jstage.jst.go.jp
Background Heart-type fatty acid-binding protein (H-FABP) is a small cytosolic protein that is
released into the circulation when the myocardium is injured. This study examined whether …

Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicin

M Yamaoka, S Yamaguchi, T Suzuki… - Journal of Molecular and …, 2000 - Elsevier
M. Yamaoka, S. Yamaguchi, T. Suzuki, M. Okuyama, J. Nitobe, N. Nakamura, Y. Mitsui and
H. Tomoike. Apoptosis in Rat Cardiac Myocytes Induced by Fas Ligand: Priming for Fas …

Increased left atrial volume index predicts a poor prognosis in patients with heart failure

H Tamura, T Watanabe, S Nishiyama, S Sasaki… - Journal of Cardiac …, 2011 - Elsevier
BACKGROUND: Left atrial volume index (LAVI) is known to reflect the duration and severity
of increased left atrial pressure caused by left ventricular (LV) diastolic dysfunction …

Risk stratification of chronic heart failure patients by multiple biomarkers implications of BNP, h-FABP, and PTX3

M Ishino, Y Takeishi, T Niizeki, T Watanabe… - Circulation …, 2008 - jstage.jst.go.jp
Background B-type natriuretic peptide (BNP), heart-type fatty acid-binding protein (H-FABP),
and pentraxin 3 (PTX3) each predict adverse cardiac events in chronic heart failure (CHF) …