Avoiding bias from weak instruments in Mendelian randomization studies
S Burgess, SG Thompson… - International journal …, 2011 - academic.oup.com
Background Mendelian randomization is used to test and estimate the magnitude of a
causal effect of a phenotype on an outcome by using genetic variants as instrumental …
causal effect of a phenotype on an outcome by using genetic variants as instrumental …
A review of instrumental variable estimators for Mendelian randomization
Instrumental variable analysis is an approach for obtaining causal inferences on the effect of
an exposure (risk factor) on an outcome from observational data. It has gained in popularity …
an exposure (risk factor) on an outcome from observational data. It has gained in popularity …
[HTML][HTML] Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies
SC Larsson, S Burgess - EBioMedicine, 2022 - thelancet.com
Background The causal association between cigarette smoking and several diseases
remains equivocal. The purpose of this study was to appraise the causal role of smoking in a …
remains equivocal. The purpose of this study was to appraise the causal role of smoking in a …
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
J Bowden, G Davey Smith… - International journal of …, 2015 - academic.oup.com
Abstract Background: The number of Mendelian randomization analyses including large
numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome …
numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome …
Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator
Developments in genome‐wide association studies and the increasing availability of
summary genetic association data have made application of Mendelian randomization …
summary genetic association data have made application of Mendelian randomization …
The MR-Base platform supports systematic causal inference across the human phenome
Results from genome-wide association studies (GWAS) can be used to infer causal
relationships between phenotypes, using a strategy known as 2-sample Mendelian …
relationships between phenotypes, using a strategy known as 2-sample Mendelian …
Mendelian randomization analysis with multiple genetic variants using summarized data
S Burgess, A Butterworth… - Genetic epidemiology, 2013 - Wiley Online Library
Genome‐wide association studies, which typically report regression coefficients
summarizing the associations of many genetic variants with various traits, are potentially a …
summarizing the associations of many genetic variants with various traits, are potentially a …
Development of emergent literacy and early reading skills in preschool children: evidence from a latent-variable longitudinal study.
Although research has identified oral language, print knowledge, and phonological
sensitivity as important emergent literacy skills for the development of reading, few studies …
sensitivity as important emergent literacy skills for the development of reading, few studies …
Changing relations between phonological processing abilities and word-level reading as children develop from beginning to skilled readers: a 5-year longitudinal …
RK Wagner, JK Torgesen, CA Rashotte… - Developmental …, 1997 - psycnet.apa.org
Relations between phonological processing abilities and word-level reading skills were
examined in a longitudinal correlational study of 216 children. Phonological processing …
examined in a longitudinal correlational study of 216 children. Phonological processing …
[HTML][HTML] Interpreting findings from Mendelian randomization using the MR-Egger method
S Burgess, SG Thompson - European journal of epidemiology, 2017 - Springer
Abstract Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …