Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …

The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern
that waning immunity may predispose to reinfection. We analyzed the magnitude and …

Background Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving
limited insights into mucosal defences that prevent viral replication and onward transmission. …

Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective
and subjective components. They are common and debilitating, and can affect the ability to …

Background: Lung clearance index (LCI) is a sensitive marker of early lung disease in children
but has not been assessed in adults. Measurement is hindered by the complexity of the …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries
a substantial risk of severe and prolonged illness; treatment options are currently limited. …

Inert gas washout tests, performed using the single- or multiple-breath washout technique,
were first described over 60 years ago. As measures of ventilation distribution inhomogeneity, …

In the last few years there has been a growing interest in lung clearance index (LCI), a
measure of lung physiology derived from multiple breath washout tests. This resurgence of …

Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19)
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…

Background Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well
characterised and clinically relevant outcome measures. Aim To evaluate a range of …