Biological effect of tissue plasminogen activator (t-PA) and DNase intrapleural delivery in pleural infection patients

Nikolaos I Kanellakis; John M Wrightson; Rob Hallifax; Eihab O Bedawi; Rachel Mercer; Maged Hassan; Rachelle Asciak; Emma Hedley; Melissa Dobson; Tao Dong; Ioannis Psallidas; Najib M Rahman

doi:10.1136/bmjresp-2019-000440

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Pleural Disease

Biological effect of tissue plasminogen activator (t-PA) and DNase intrapleural delivery in pleural infection patients

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Nikolaos I Kanellakis Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UKLaboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, UKNational Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
John M Wrightson Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Rob Hallifax Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Eihab O Bedawi Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Rachel Mercer Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Maged Hassan Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Rachelle Asciak Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Emma Hedley Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Melissa Dobson Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Tao Dong Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UKMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Ioannis Psallidas Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UKLaboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK PubMed articles Google scholar articles
Najib M Rahman Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UKLaboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, UKNational Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, Oxfordshire, UK PubMed articles Google scholar articles

Correspondence to Dr Nikolaos I Kanellakis, Laboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, U, University of Oxford, Oxford, Oxfordshire OX3 7LJ, UK; nikolaos.kanellakis{at}ndm.ox.ac.uk

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Citation

Kanellakis NI, Wrightson JM, Hallifax R, et al

Biological effect of tissue plasminogen activator (t-PA) and DNase intrapleural delivery in pleural infection patients

BMJ Open Respiratory Research 2019;6:e000440. doi: 10.1136/bmjresp-2019-000440

Publication history

Received April 9, 2019
Revised September 7, 2019
Accepted September 12, 2019
First published September 24, 2019.

Online issue publication

June 21, 2023

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.