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P057 Sleep in patients living with mesothelioma: a scoping review
  1. Karamo Cham and
  2. Alex Perkins
  1. Swansea University, Swansea, UK


Introduction Poor sleep quality is common for patients living with cancer,1 and is linked with poor quality of life, psychological disorders, and poor outcomes.2 Interventions designed to optimise sleep quality therefore have the potential to improve patient wellbeing.3 This may be important for people living with cancers such as mesothelioma, where a poor prognosis may tend towards palliative management regimes.

Few studies have attempted to describe the scale or nature of poor sleep quality in patients living with mesothelioma, so this review aims to establish the type of sleep-related outcomes that have been applied in studies of this population.

Method The PubMed database was used to search for studies that have included measures of sleep, or sleep quality in patients living with mesothelioma. Search terms included: Mesothelioma AND (Sleep* OR Tiredness).

Results The initial search yielded 160 results, after eligibility screening 16 full text studies were included in the qualitative synthesis (see figure 1). The most common method of evaluating sleep or sleep quality in mesothelioma was the EORTC QLQ-C30 questionnaire.4 Other methods included the lung cancer symptom scale,5 and the Sheffield Profile for Assessment and Referral to Care,6 as well as various un-validated or subjective free-text responses (see table 1).

Abstract P057 Figure 1

Eligibility and screening flow-chart. 125 results were excluded as not being relevant, and 8 studies could not be accessed. A further 11 full-text studies were excluded as they did not include sleep-related measures. A total 16 full-text studies were included in the analysis

Abstract P057 Table 1

Summary of sleep-related measures used in mesothelioma populations

Discussion The studies identified have included fairly superficial measures of sleep or sleep quality (see table 1). Items in the generic cancer-related quality of life questionnaires relate to ‘difficulty’ or ‘trouble’ sleeping, as well as daytime sleepiness. There were no studies using objectives or subjective measures of sleep such as actigraphy or diaries, and no sleep-specific quality of life questionnaires.

Conclusion Further work is required to understand the nature and impact of poor sleep quality in this population. This should include objective measurement, sleep-specific questionnaires, and qualitative analysis.


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