Objectives Death or hospital readmission are frequent among patients surviving acute hypercapnic respiratory failure (AHRF). Severity scores are not valid to predict death or readmission after AHRF. Gait speed, a simple functional parameter, has been associated with hospital admission and death in the general population. The purpose of this study is to highlight an association between gait speed at hospital discharge and death or readmission among AHRF survivors.
Design Secondary analysis of a prospective cohort study.
Settings Single Swiss tertiary hospital, pulmonary division.
Participants Patients were prospectively recruited to form a cohort of patients surviving AHRF in the intensive care unit between January 2012 and May 2015.
Outcome measure Gait speed was derived from a 6 min walking test (6MWT) before hospital discharge. All predictive variables were prospectively collected. Death or hospital readmission were recorded for 6 months. Univariate and multivariate analyses were performed to evaluate the association between predictive variables and death or hospital readmission.
Results 71 patients performed a 6MWT. 34/71 (48%) patients died or were readmitted to the hospital during the observation period. Median gait speed was 0.7 (IQR 0.3–1.0) m/s. At 6 months, 66% (25/38) of slow walkers (gait speed <0.7 m/s) and 27% (9/33) of non-slow walkers died or were readmitted to the hospital (p=0.002). In univariate analysis, gait speed was associated with death or readmission (HR 0.41; 95% CI 0.19 to 0.90, p=0.025). In a multivariate model adjusted for age, gender, body mass index, forced expired volume, heart failure and home mechanical ventilation, gait speed remained the only variable associated with death or readmission (multivariate HR: 0.35; 95% CI 0.14 to 0.88, p=0.025).
Conclusion This study suggests that a simple functional parameter such as gait speed is associated with death or hospital readmission in patients surviving AHRF.
Trial registration number NCT02111876.
- non invasive ventilation
- pulmonary rehabilitation
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What is the key question?
Could gait speed be associated with death or readmission among patients surviving acute hypercapnic respiratory failure (AHRF)?
What is the bottom line?
Gait speed, measured on hospital discharge in patients surviving AHRF, is associated with death or readmission at 6 months.
Why read on?
This is one of the first study to demonstrate an association between gait speed and death or hospital readmission among patients surviving AHRF. Given the poor prognosis after an index episode of AHRF, improving risk stratification might contribute to better individualise therapeutic interventions and identify patients who would benefit from rehabilitation or integrated care programmes.
Strengths and limitations of this study
This study is based on a prospective cohort of patient recruited after an acute hypercapnic respiratory failure in the intensive care unit.
Gait speed assessment is standardised and easily reproducible and may provide important prognostic information.
The primary outcome includes death and readmission, two clinically relevant outcomes.
The main limitation is the size of the sample limiting the precision of the strength of association estimates.
Acute hypercapnic respiratory failure (AHRF) is a turning point in the course of chronic obstructive pulmonary disease (COPD) and other causes of chronic respiratory failure. Non-invasive ventilation (NIV) reduces the intubation rate and in-hospital mortality in patients with AHRF, and allows to treat patients with advanced disease including those who decline intubation.1–5 However, longer term prognosis after an index episode of AHRF remains poor with a median survival of less than 4 years.6 7 In a prospective cohort of patients with COPD surviving AHRF, one half of patients died at 1 year and two-thirds experienced another life-threatening event.8 After a second admission for AHRF, patients typically enter a deteriorating health trajectory with more frequent and severe exacerbations until death.5 Therefore, prognostic assessment of those surviving AHRF is of importance to provide specific interventions or discuss advanced care planning.
Traditional scores combining pulmonary function, the history of past exacerbations and comorbidities, such as Body-mass index, airflow Obstruction, Dyspnea, and Exercise Index and Comorbidity, age, Obstruction, Dyspnea, and previous severe EXacerbations, have been validated to compute outcome of stable patients with COPD or those experiencing an exacerbation but have not been tested in a specific population of patients surviving AHRF in the intensive care unit (ICU).9 10 Comorbidities are significantly associated with a longer length of stay but poorly predict 3 months death or readmission among AHRF survivors.11 Therefore, simple predictors of death or hospital readmission in this setting are required.
Frailty is a common problem among patients with chronic respiratory insufficiency and sarcopenia affects up to 15% of patients with COPD.12 13 Gait speed is a key marker of frailty as it integrates multisystem function including sensory perception, motor function, coordination, nutritional status, cognitive status and cardiac–respiratory function. Gait speed has been shown to predict mortality in elderly patients with significant increments per 0.1 m/s.14 Among patients with respiratory conditions, such as idiopathic pulmonary fibrosis, gait speed better predicts mortality than gender, age or a clinical tool combining those variables with pulmonary function tests.15 However, gait speed has not been studied to predict mortality or hospital readmission in patients with AHRF.
We hypothesised that gait speed measured prospectively on hospital discharge is associated with death or hospital readmission after an admission in the ICU for AHRF.
We performed a secondary analysis of a single-centre prospective cohort recruited at the Geneva University Hospitals between January 2012 and May 2015. The detailed methods and main results of this cohort have been detailed elsewhere.11 Briefly, consecutive patients surviving AHRF were recruited at ICU discharge. AHRF was defined by a pH <7.35 with an arterial carbon dioxide tension (PaCO2) of >6.3 kPa and the need for invasive or non-invasive ventilation (NIV). Exclusion criteria were: age younger than 18 years old, neuromuscular disease, pregnancy, iatrogenic respiratory failure, life expectancy of less than 3 months, confusion despite total/partial blood gas normalisation, or major psychiatric disease, absence of 6 min walking test. Demographic data were collected at ICU discharge. Pulmonary function tests and echocardiography were systematically performed before hospital discharge, usually between 7 and 15 days after ICU discharge. Heart failure was diagnosed based on history and physical examination and evidence of systolic (left ventricular ejection fraction <55%) or diastolic dysfunction. Gait speed in (m/s) was computed using a 6 min walking test performed at hospital discharge. Mean gait speed was obtained by dividing the 6 min distance walk in metres by time in seconds. The primary outcome combined death or hospital readmission. Hospital readmission or death were prospectively recorded at regular intervals for 6 months by reviewing medical records or through telephone calls to the patients or to family members.
Participant and public involvement
All patients provided written informed consent. Patients had no involvement in the design, the conduct of the study and the writing of the manuscript.
Descriptive statistics are reported as counts and percentages for categorical data and means and SD or the median and IQR for continuous variables. We constructed a Kaplan-Meier cumulative-event curve for hospital-free survival. Surviving patients were defined as patients alive without hospital readmission. The data were censored at 6 months after ICU discharge. Log-rank test was used to compare the curves in two groups (categorical classification of slow walkers vs non-slow walkers). Slow walkers were defined as patients with gait speed inferior to the observed median in our cohort expressed in metre/second rounded to the tenth. To evaluate the strength of association between gait speed and our primary outcome, a regression model (Cox proportional hazard model) was built using gait speed, treated as a continuous variable. Univariate and multivariate analyses were computed including age, gender and prespecified risk factors for readmission such as body mass index (BMI), forced expiratory volume in one second (FEV1; treated as continuous variables), home mechanical ventilation (HMV) and heart failure. A p value of<0.05 was considered statistically significant. HRs are given with 95% CIs. All analyses were performed using STATA V.14.2 (Statacorp).
Of the 78 patients included in the original cohort, 71 (85%) had a 6MWT recorded in our database. Characteristics of the study population are provided in table 1. Median gait speed was 0.7 m/s (IQR 0.3–1.0 m/s). Thirty-four patients (48%) died or were readmitted to the hospital during the observation period of 6 months. Of those, 25 (74%) were slow walkers, as defined by a gait speed of less than 0.7 m/s, and 9 (26%) were non-slow walkers. Among 37 patients who did not reach the primary outcome, 13 (35%) were slow walkers and 24 (65%) were non-slow walkers. The 6 months rate of death or readmission was 66% (25/38; 95% CI 49% to 80%) among slow walkers and 27% (9/33; 95% CI 13% to 46%) among non-slow walkers (p=0.002; figure 1). In univariate analysis, gait speed, treated as a continuous variable, was associated with the primary outcome (HR 0.41; 95% CI 0.19 to 0.90), while age, gender, BMI, heart failure, FEV1 and being discharged with HMV were not (table 2). In the multivariate model including age, gender, BMI, FEV1, heart failure and HMV, gait speed remained the only variable associated with death or readmission (multivariate HR: 0.35, 95% CI 0.14 to 0.88, p=0.025; table 2).
In this secondary analysis of a prospective cohort study, gait speed was significantly associated with death or hospital readmission among AHRF survivors. The likelihood to reach the outcome decreased by about three times for every 1 m/s increase in gait speed (multivariate HR: 0.35). By contrast, age, FEV1, heart failure, BMI and discharge with home NIV were not associated with 6 months death or readmission.
These results suggest that gait speed, as a measure of functional status, might be of importance for risk stratification in patients surviving AHRF. Our results are consistent with previous observations reporting the prognostic importance of gait speed in other settings.14 16 In a pooled analysis of 9 cohort studies including 34 485 older adults aged 65 years or older, Studenski et al reported an association between gait speed and 10-year survival among older patients with an overall HR for mortality of 0.88 (0.87 to 0.90), after adjusting for gender, BMI, smoking or medical history. The association between gait speed and mortality or readmission was also reported among patients with chronic respiratory diseases,15 chronic heart failure17 and patients undergoing post cardiac rehabilitation.18 In a cohort of 130 patients with idiopathic pulmonary fibrosis, Nolan et al also reported a significant association between gait speed and all-cause mortality or hospital admission. Multivariate models including gait speed had better discrimination for predicting mortality than a clinical tool to predict idiopathic pulmonary fibrosis outcome combining gender, age, forced vital capacity and diffuse capacity of the lung for carbon monoxide.15 Moreover, gait speed is a consistent predictor of mortality among ambulatory patients with COPD and elderly patients with COPD admitted to the hospital for an acute exacerbation.19 20
The prognostic importance of gait speed illustrates the importance of functional parameters among patients with respiratory failure. Although previous studies usually calculated gait speed using a 4-metre gait speed (4MGS), the proposed cut-off values were very similar to our with proposed values between 0.7 and 1 m/s.14 21 22 The correlation between 4MGS and 6MWT and functional capacity has been demonstrated among patients with COPD and other causes of respiratory failure.23 24 Measure of gait speed using very short distances such as the 4 m gait speed or the timed up and go test is gaining widespread popularity because it can be performed in very frail patients as well as at the doctor’s office.25 Gait speed is an integrative measure including respiratory and cardiac capacity, cognitive status, motor function, coordination, sensory perception and nutritional status.26 Moreover, decreased mobility may further result in reduced physical activity and deconditioning which may lead to decreased survival.27 The concept of frailty, a progressive decline in multiorgan function, has gained popularity among geriatricians and respiratory physicians.28–30 Frailty not only represents an important prognostic predictor, but may also represent a target for multidimensional interventions. Multimodal and pluriprofessional interventions aiming to restore functional capacity such as integrated care pathways have been developed for patients with airway disease and pulmonary rehabilitation programmes have been shown to reduce hospital readmission or death after COPD exacerbation.31–35 Therefore, risk stratification based on simple functional parameters such as gait speed might contribute to better identify patients who would benefit from these interventions.
Our study has several strengths. First, we included consecutive patients with various aetiologies of respiratory failure. Second, predictive variables and outcome assessment were prospectively recorded and outcome assessors were blinded for the results of predictive variables. Gait speed assessment was standardised in order to assure its reproducibility. Our study has also several limitations. First, we used a convenient sample size limiting the power of our measures of association and the precision of the strength of association estimates and preventing us to separately analyse death and readmission. This could contribute to the absence of significant association between traditional variables and outcome. Moreover, we included all prespecified clinically relevant variables in our multivariate model which resulted in a non-parsimonious model which has been reported to increase the risk of spurious findings. However, the rate of the primary outcome was sufficient to obtain a highly significant association between gait speed and death or readmission. Second, patients were allowed to stop during the 6MWT, but the duration of the stop was not recorded. In these cases, the gait speed might have been underestimated, especially among the most affected patients. Moreover, oxygen therapy during 6MWT was not recorded. Finally, given the observational nature of this study, further research is required to evaluate if improved prognostic assessment of patients surviving AHRF would improve their management and prognosis.
Our data suggest that gait speed, as simple functional parameter, is associated with death or hospital readmission in patients surviving AHRF. Improved risk stratification of these patients might contribute to better individualise therapeutic interventions and better identify patients who would benefit from rehabilitation or integrated care programmes.
DA and CM contributed equally.
Presented at The present work was presented as an abstract at the Swiss Society of General Internal Medicine Congress in June 2019.
Contributors GK, CM and DA conceived and designed the study; drafted the manuscript. DA conceived the original study and analysed the data. GA and DZ participated to the study by critically reviewing the manuscript. All authors approved the final version.
Funding The study was supported by the “Ligue Pulmonaire Genevoise” and by the research Fund of the Department of Internal Medicine of the University Hospital and Faculty of Medicine of Geneva.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Patient consent for publication Not required.
Ethics approval The study protocol was approved by the University of Geneva institutional review board (#11-238) and registered at www.clinicaltrials.gov (identifier NCT02111876).
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available upon reasonable request.
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