PT - JOURNAL ARTICLE AU - N R Qureshi AU - R C Rintoul AU - K A Miles AU - S George AU - S Harris AU - J Madden AU - K Cozens AU - L A Little AU - K Eichhorst AU - J Jones AU - P Moate AU - C McClement AU - L Pike AU - D Sinclair AU - W L Wong AU - J Shekhdar AU - R Eaton AU - A Shah AU - L Brindle AU - C Peebles AU - A Banerjee AU - S Dizdarevic AU - S Han AU - F W Poon AU - A M Groves AU - L Kurban AU - A J Frew AU - M E Callister AU - P Crosbie AU - F V Gleeson AU - K Karunasaagarar AU - O Kankam AU - F J Gilbert TI - Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules—the SPUtNIk study AID - 10.1136/bmjresp-2016-000156 DP - 2016 Oct 01 TA - BMJ Open Respiratory Research PG - e000156 VI - 3 IP - 1 4099 - http://bmjopenrespres.bmj.com/content/3/1/e000156.short 4100 - http://bmjopenrespres.bmj.com/content/3/1/e000156.full SO - BMJ Open Resp Res2016 Oct 01; 3 AB - Introduction Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently.Methods and analysis The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) (18FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for 18FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs.Ethics and dissemination Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals.Trial registration number ISRCTN30784948; Pre-results.