PT  - JOURNAL ARTICLE
AU  - Ivan Tang
AU  - Chris D Turnbull
AU  - Dushendree Sen
AU  - Sonya Craig
AU  - Malcolm Kohler
AU  - John R Stradling
TI  - Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
AID  - 10.1136/bmjresp-2020-000742
DP  - 2020 Sep 01
TA  - BMJ Open Respiratory Research
PG  - e000742
VI  - 7
IP  - 1
4099  - http://bmjopenrespres.bmj.com/content/7/1/e000742.short
4100  - http://bmjopenrespres.bmj.com/content/7/1/e000742.full
SO  - BMJ Open Resp Res2020 Sep 01; 7
AB  - The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. We now present long-term MOSAIC study follow-up data. Median (first quartile, third quartile) follow-up was 5.0 (2.2, 5.0) and 3.7 (1.5, 5.0) years for CPAP and standard care, respectively. Compared to standard care, CPAP had no statistically significant effect on the risk of cardiovascular events (HR=0.83, p=0.54, 95% CI 0.46–1.51).