RT Journal Article
SR Electronic
T1 Symptomatic, biochemical and radiographic recovery in patients with COVID-19
JF BMJ Open Respiratory Research
JO BMJ Open Resp Res
FD British Thoracic Society
SP e000908
DO 10.1136/bmjresp-2021-000908
VO 8
IS 1
A1 Patrick Mallia
A1 Jamilah Meghji
A1 Brandon Wong
A1 Kartik Kumar
A1 Victoria Pilkington
A1 Shaan Chhabra
A1 Ben Russell
A1 Jian Chen
A1 Karthikan Srikanthan
A1 Mirae Park
A1 Harriet Owles
A1 Felicity Liew
A1 Joana Alcada
A1 Laura Martin
A1 Meg Coleman
A1 Sarah Elkin
A1 Clare Ross
A1 Shweta Agrawal
A1 Thomas Gardiner
A1 Aaron Bell
A1 Alice White
A1 Dominic Hampson
A1 Gauri Vithlani
A1 Kavina Manalan
A1 Solange Bramer
A1 Alejandra Martin Segura
A1 Anushree Kucheria
A1 Prashanthi Ratnakumar
A1 Alexander Sheeka
A1 Lavanya Anandan
A1 Susan Copley
A1 Georgina Russell
A1 Chloe I Bloom
A1 Onn Min Kon
YR 2021
UL http://bmjopenrespres.bmj.com/content/8/1/e000908.abstract
AB Background The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.Methods Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.Results 75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR-positive and PCR-negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.Conclusions Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow-up of patients with COVID-19.All data relevant to the study are included in the article or uploaded as supplemental information. All data are contained in the manuscript.