RT Journal Article
SR Electronic
T1 Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic
JF BMJ Open Respiratory Research
JO BMJ Open Resp Res
FD British Thoracic Society
SP e000915
DO 10.1136/bmjresp-2021-000915
VO 8
IS 1
A1 Hana B Ruran
A1 Gary Adamkiewicz
A1 Amparito Cunningham
A1 Carter R Petty
A1 Kimberly F Greco
A1 Sigfus Gunnlaugsson
A1 Natalie Stamatiadis
A1 Gabriella Sierra
A1 Jose Vallarino
A1 Marty Alvarez
A1 Lystra P Hayden
A1 Catherine A Sheils
A1 Edie Weller
A1 Wanda Phipatanakul
A1 Jonathan M Gaffin
YR 2021
UL http://bmjopenrespres.bmj.com/content/8/1/e000915.abstract
AB Introduction Almost half of all school-age children with bronchopulmonary dysplasia (BPD) have asthma-like symptoms and more suffer from lung function deficits. While air pollution and indoor respiratory irritants are known to affect high-risk populations of children, few studies have objectively evaluated environmental contributions to long-term respiratory morbidity in this population. This study aimed to examine the role of indoor environmental exposures on respiratory morbidity in children with BPD.Methods and analysis The Air quality, Environment and Respiratory Ouctomes in BPD (AERO-BPD) study is a prospective, single-centre observational study that will enrol a unique cohort of 240 children with BPD and carefully characterise participants and their indoor home environmental exposures. Measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), nitric oxide (NO), temperature and humidity, as well as dust concentrations of allergens, with concurrently measured respiratory symptoms and lung function.Adaptations to the research protocol due to the SARS-CoV-2 pandemic included remote home environment and participant assessments.Ethics and dissemination Study protocol was approved by the Boston Children’s Hospital Committee on Clinical Investigation. Dissemination will be in the form of peer-reviewed publications and participant information products.Trial registration number NCT04107701.