TY - JOUR T1 - Coil embolisation for massive haemoptysis in cystic fibrosis JF - BMJ Open Respiratory Research JO - BMJ Open Resp Res DO - 10.1136/bmjresp-2021-000985 VL - 8 IS - 1 SP - e000985 AU - Martha Dohna AU - Diane Miriam Renz AU - Florian Stehling AU - Christian Dohna-Schwake AU - Sivagurunathan Sutharsan AU - Claus Neurohr AU - Hubert Wirtz AU - Olaf Eickmeier AU - Jörg Grosse-Onnebrink AU - Axel Sauerbrey AU - Volker Soditt AU - Krystyna Poplawska AU - Frank Wacker AU - Michael Johannes Montag Y1 - 2021/08/01 UR - http://bmjopenrespres.bmj.com/content/8/1/e000985.abstract N2 - Introduction Massive haemoptysis is a life-threatening event in advanced cystic fibrosis (CF) lung disease with bronchial artery embolisation (BAE) as standard of care treatment. The aim of our study was to scrutinise short-term and long-term outcomes of patients with CF and haemoptysis after BAE using coils.Methods We carried out a retrospective cohort study of 34 adult patients treated for massive haemoptysis with super selective bronchial artery coil embolisation (ssBACE) between January 2008 and February 2015. Embolisation protocol was restricted to the culprit vessel(s) and three lobes maximum. Demographic data, functional end-expiratory volume in 1 s in % predicted (FEV1% pred.) and body mass index before and after ssBACE, sputum colonisation, procedural data, time to transplant and time to death were documented.Results Patients treated with ssBACE showed significant improvement of FEV1% pred. after embolisation (p=0.004) with 72.8% alive 5 years post-ssBACE. Mean age of the patients was 29.9 years (±7.7). Mean FEV1% pred. was 45.7% (±20.1). Median survival to follow-up was 75 months (0–125). Severe complication rate was 0%, recanalisation rate 8.8% and 5-year-reintervention rate 58.8%. Chronic infection with Pseudomonas aeruginosa was found in 79.4%, Staphylococcus areus in 50% and Aspergillus fumigatus in 47.1%.Discussion ssBACE is a safe and effective treatment for massive haemoptysis in patients with CF with good results for controlling haemostasis and excellent short-term and long-term survival, especially in severely affected patients with FEV<40% pred. We think the data of our study support the use of coils and a protocol of careful and prudent embolisation.All data relevant to the study are included in the article or uploaded as supplemental information. ER -