RT Journal Article
SR Electronic
T1 Risk factors of mortality among patients hospitalised with COVID-19 in a critical care or hospital care unit: analysis of the French national medicoadministrative database
JF BMJ Open Respiratory Research
JO BMJ Open Resp Res
FD British Thoracic Society
SP e001002
DO 10.1136/bmjresp-2021-001002
VO 8
IS 1
A1 Eric Ouattara
A1 Amelie Bruandet
A1 Aurélie Borde
A1 Xavier Lenne
A1 Florence Binder-Foucard
A1 Maggie Le-bourhis-zaimi
A1 Joris Muller
A1 Pierre Tran ba loc
A1 Fabienne Séguret
A1 Sophie Tezenas du Montcel
A1 Véronique Gilleron
YR 2021
UL http://bmjopenrespres.bmj.com/content/8/1/e001002.abstract
AB Objective To explore mortality risk factors for patients hospitalised with COVID-19 in a critical care unit (CCU) or a hospital care unit (HCU).Design Retrospective cohort analysis using the French national (Programme de médicalisation des systèmes d’information) database.Setting Any public or private hospital in France.Participants 98 366 patients admitted with COVID-19 for more than 1 day during the first semester of 2020 were included. The underlying conditions were retrieved for all contiguous stays.Main outcome measures In-hospital mortality and associated risk factors were assessed using frailty Cox models.Results Among the 98 366 patients included, 25 765 (26%) were admitted to a CCU. The median age was 66 (IQR: 55–76) years in CCUs and 74 (IQR: 57–85) years in HCUs. Age was the main risk factor of death in both CCUs and HCUs, with adjusted HRs (aHRs) in CCUs increasing from 1.60 (95% CI 1.35 to 1.88) for 46 to 65 years to 8.17 (95% CI 6.86 to 9.72) for ≥85 years. In HCUs, the aHR associated with age was more than two times higher. The gender was not significantly associated with death, aHR 1.03 (95% CI 0.98 to 1.09, p=0.2693) in CCUs. Most of the underlying chronic conditions were risk factors for death, including malignant neoplasm (CCU: 1.34 (95% CI 1.25 to 1.43); HCU: 1.41 (95% CI 1.35 to 1.47)), cirrhosis without transplant (1.41 (95% CI 1.22 to 1.64); 1.27 (95% CI 1.12 to 1.45)) and dementia (1.30 (95% CI 1.16 to 1.46); 1.07 (95% CI 1.03 to 1.12)).Conclusion This analysis confirms the role of age as the major risk factor of death in patients with COVID-19 irrespective to admission to critical care and therefore supports the current vaccination policies targeting older individuals.Data may be obtained from a third party and are not publicly available.