@article {Coxe001107, author = {Narelle S Cox and Aroub Lahham and Christine F McDonald and Ajay Mahal and Paul O{\textquoteright}Halloran and Graham Hepworth and Lissa Spencer and Renae J McNamara and Janet Bondarenko and Heather Macdonald and Samantha Gavin and Angela T Burge and Caitlin Le Maitre and Cade Ringin and Elizabeth Webb and Amanda Nichols and Ling-Ling Tsai and Nia Luxton and Stephanie van Hilten and Mary Santos and Hayley Crute and Megan Byrne and Helen Boursinos and Jennifer Broe and Monique Corbett and Tunya Marceau and Brooke Warrick and Claire Boote and Joanna Melinz and Anne E Holland}, title = {Home-based pulmonary rehabilitation early after hospitalisation in COPD (early HomeBase): protocol for a randomised controlled trial}, volume = {8}, number = {1}, elocation-id = {e001107}, year = {2021}, doi = {10.1136/bmjresp-2021-001107}, publisher = {Archives of Disease in childhood}, abstract = {Introduction Chronic obstructive pulmonary disease (COPD) is characterised by exacerbations of respiratory disease, frequently requiring hospital admission. Pulmonary rehabilitation can reduce the likelihood of future hospitalisation, but programme uptake is poor. This study aims to compare hospital readmission rates, clinical outcomes and costs between people with COPD who undertake a home-based programme of pulmonary rehabilitation commenced early (within 2 weeks) of hospital discharge with usual care.Methods A multisite randomised controlled trial, powered for superiority, will be conducted in Australia. Eligible patients admitted to one of the participating sites for an exacerbation of COPD will be invited to participate. Participants will be randomised 1:1. Intervention group participants will undertake an 8-week programme of home-based pulmonary rehabilitation commencing within 2 weeks of hospital discharge. Control group participants will receive usual care and a weekly phone call for attention control. Outcomes will be measured by a blinded assessor at baseline, after the intervention (week 9{\textendash}10 posthospital discharge), and at 12 months follow-up. The primary outcome is hospital readmission at 12 months follow-up.Ethics and dissemination Human Research Ethics approval for all sites provided by Alfred Health (Project 51216). Findings will be published in peer-reviewed journals, conferences and lay publications.Trial registration number ACTRN12619001122145.}, URL = {https://bmjopenrespres.bmj.com/content/8/1/e001107}, eprint = {https://bmjopenrespres.bmj.com/content/8/1/e001107.full.pdf}, journal = {BMJ Open Respiratory Research} }