RT Journal Article SR Electronic T1 Health economic analysis for the ‘CURE Project’ pilot: a hospital-based tobacco dependency treatment service in Greater Manchester JF BMJ Open Respiratory Research JO BMJ Open Resp Res FD British Thoracic Society SP e001105 DO 10.1136/bmjresp-2021-001105 VO 8 IS 1 A1 Evison, Matthew A1 Cox, Julian A1 Howle, Freya A1 Groom, Kathryn A1 Moore, Ryan A1 Clegg, Hannah A1 Pearse, Cheryl A1 Rutherford, Michael A1 Tempowski, Alex A1 Grundy, Seamus A1 Turnpenny, Beth A1 Law, Hou A1 Sundar, Ram A1 Butt, Al-Tahoor A1 Abdelaziz, Muntasir A1 Coyne, Jane A1 Crossfield, Andrea A1 O’Rourke, Claire A1 Shackley, David YR 2021 UL http://bmjopenrespres.bmj.com/content/8/1/e001105.abstract AB Introduction Treating tobacco dependency in patients admitted to acute care National Health Service (NHS) trusts is a key priority in the NHS 10-year plan. This paper sets out the results of a health economic analysis for ‘The CURE Project’ pilot; a new hospital-based tobacco dependency service.Methods A health economic analysis to understand the costs of the intervention (both for the inpatient service and postdischarge costs), the return on investment (ROI) and the cost per quality-adjusted life year (QALY) of the CURE Project pilot in Greater Manchester. ROI and cost per QALY were calculated using the European Study on Quantifying Utility of Investment in Protection from Tobacco and Greater Manchester Cost Benefit Analysis Tools.Results The total intervention costs for the inpatient service in the 6-month CURE pilot were £96 224 with a cost per patient who smokes of £40.21. The estimated average cost per patient who was discharged on pharmacotherapy was £97.40. The cost per quit (22% quit rate for smokers at 12 weeks post discharge) was £475. The gross financial ROI ratio was £2.12 return per £1 invested with a payback period of 4 years. The cashable financial ROI ratio was £1.06 return per £1 invested with a payback period of 10 years. The public value ROI ratio was £30.49 per £1 invested. The cost per QALY for this programme was £487.Discussion The CURE Project pilot has been shown to be exceptionally cost-effective with highly significant ROI in this health economic analysis. This supports the NHS priority to embed high-quality tobacco addiction treatment services in acute NHS trusts, and the CURE Project provides a blueprint and framework to achieve this.No data are available.