@article {Keladae001139, author = {Lauren Kelada and Claire Wakefield and Nada Vidic and David S Armstrong and Bruce Bennetts and Kirsten Boggs and John Christodoulou and Joanne Harrison and Gladys Ho and Nitin Kapur and Suzanna Lindsey-Temple and Tim McDonald and David Mowat and Andr{\'e} Schultz and Hiran Selvadurai and Andrew Tai and Adam Jaffe}, title = {Genomic testing for children with interstitial and diffuse lung disease (chILD): parent satisfaction, understanding and health-related quality of life}, volume = {9}, number = {1}, elocation-id = {e001139}, year = {2022}, doi = {10.1136/bmjresp-2021-001139}, publisher = {Archives of Disease in childhood}, abstract = {Objective Research is needed to determine best practice for genomic testing in the context of child interstitial or diffuse lung disease (chILD). We explored parent{\textquoteright}s and child{\textquoteright}s health-related quality of life (HRQoL), parents{\textquoteright} perceived understanding of a genomic testing study, satisfaction with information and the study and decisional regret to undertake genomic testing.Methods Parents of children with diagnosed or suspected chILD who were enrolled in a genomic sequencing study were invited to complete questionnaires pretesting (T1) and after receiving the result (T2).Results Parents{\textquoteright} (T1, n=19; T2, n=17) HRQoL was lower than population norms. Study satisfaction (T1) and perceived understanding (T2) were positively correlated (rs=0.68, p=0.014). Satisfaction with information (T1 and T2) and decisional regret (T2) were negatively correlated (T1 rs=-0.71, p=0.01; T2 rs=-0.56, p=0.03). Parents reported wanting more frequent communication with staff throughout the genomic sequencing study, and greater information about the confidentiality of test results.Conclusions Understanding of genomic testing, satisfaction with information and participation and decisional regret are inter-related. Pretest consultations are important and can allow researchers to explain confidentiality of data and the variable turnaround times for receiving a test result. Staff can also update parents when there will be delays to receiving a result.Data are available on reasonable request. Deidentified participant data are available from the corresponding author (https://orcid.org/0000-0001-9428-8807) on reasonable request.}, URL = {https://bmjopenrespres.bmj.com/content/9/1/e001139}, eprint = {https://bmjopenrespres.bmj.com/content/9/1/e001139.full.pdf}, journal = {BMJ Open Respiratory Research} }