RT Journal Article SR Electronic T1 Genomic testing for children with interstitial and diffuse lung disease (chILD): parent satisfaction, understanding and health-related quality of life JF BMJ Open Respiratory Research JO BMJ Open Resp Res FD British Thoracic Society SP e001139 DO 10.1136/bmjresp-2021-001139 VO 9 IS 1 A1 Kelada, Lauren A1 Wakefield, Claire A1 Vidic, Nada A1 Armstrong, David S A1 Bennetts, Bruce A1 Boggs, Kirsten A1 Christodoulou, John A1 Harrison, Joanne A1 Ho, Gladys A1 Kapur, Nitin A1 Lindsey-Temple, Suzanna A1 McDonald, Tim A1 Mowat, David A1 Schultz, André A1 Selvadurai, Hiran A1 Tai, Andrew A1 Jaffe, Adam YR 2022 UL http://bmjopenrespres.bmj.com/content/9/1/e001139.abstract AB Objective Research is needed to determine best practice for genomic testing in the context of child interstitial or diffuse lung disease (chILD). We explored parent’s and child’s health-related quality of life (HRQoL), parents’ perceived understanding of a genomic testing study, satisfaction with information and the study and decisional regret to undertake genomic testing.Methods Parents of children with diagnosed or suspected chILD who were enrolled in a genomic sequencing study were invited to complete questionnaires pretesting (T1) and after receiving the result (T2).Results Parents’ (T1, n=19; T2, n=17) HRQoL was lower than population norms. Study satisfaction (T1) and perceived understanding (T2) were positively correlated (rs=0.68, p=0.014). Satisfaction with information (T1 and T2) and decisional regret (T2) were negatively correlated (T1 rs=−0.71, p=0.01; T2 rs=−0.56, p=0.03). Parents reported wanting more frequent communication with staff throughout the genomic sequencing study, and greater information about the confidentiality of test results.Conclusions Understanding of genomic testing, satisfaction with information and participation and decisional regret are inter-related. Pretest consultations are important and can allow researchers to explain confidentiality of data and the variable turnaround times for receiving a test result. Staff can also update parents when there will be delays to receiving a result.Data are available on reasonable request. Deidentified participant data are available from the corresponding author (https://orcid.org/0000-0001-9428-8807) on reasonable request.