RT Journal Article SR Electronic T1 Differences in risk indicators associated with electronic cigarette use and tobacco smoking among adolescents and young people in Nigeria JF BMJ Open Respiratory Research JO BMJ Open Resp Res FD British Thoracic Society SP e001285 DO 10.1136/bmjresp-2022-001285 VO 9 IS 1 A1 Morenike Oluwatoyin Folayan A1 Omolola Alade A1 Yewande Adeyemo A1 Heba Jafar Sabbagh A1 Afolabi Oyapero A1 Elizabeth O Oziegbe A1 Bamidele Olubukola Popoola A1 Maryam Quritum A1 Maha El Tantawi YR 2022 UL http://bmjopenrespres.bmj.com/content/9/1/e001285.abstract AB Introduction The study determined the proportion of adolescents and young persons (AYP) in Nigeria who use e-cigarettes and smoke tobacco; and identified factors associated with the use of e-cigarettes and tobacco smoking.Methods AYP aged 11–23 years were recruited to participate in an online survey. The independent variables were respondents’ health, HIV and COVID-19 status and their level of anxiety. The dependent variables were tobacco smoking and use of e-cigarettes. Binary logistic regression was used to determine the associations between the dependent and independent variables after adjusting for confounders (age, sex, educational level and vulnerability status).Results There were 2206 respondents of which 568 (19.8%) used e-cigarettes and 787 (27.4%) smoked tobacco. Individual (18–23 years, having a health condition, high anxiety and being vulnerable) and familial (having father, mother, siblings or friends who used e-cigarettes) factors were associated with both the use of e-cigarettes and tobacco smoking. Tobacco smoking was a significant risk indicator for e-cigarettes use and vice versa. COVID-19 infection (adjusted OR, AOR: 3.602) and living with HIV (AOR: 1.898) were associated with higher odds of using e-cigarettes. Males (AOR: 1.577), 15–17 years (AOR: 6.621) and moderate anxiety (AOR: 2.500) were associated with higher odds of tobacco smoking. AYP with health conditions had higher odds of using e-cigarettes (AOR: 1.514) while AYP with moderate anxiety had lower odds of using e-cigarettes (AOR: 0.627).Conclusion The proportion of AYP in Nigeria who used e-cigarettes and smoked tobacco is high. Public health interventions that target the common risk factors for e-cigarettes use and tobacco smoking among AYP in Nigeria are urgently needed.Data are available on reasonable request.