RT Journal Article
SR Electronic
T1 Decreased capsaicin cough reflex sensitivity predicts hospitalisation due to COPD
JF BMJ Open Respiratory Research
JO BMJ Open Resp Res
FD British Thoracic Society
SP e001283
DO 10.1136/bmjresp-2022-001283
VO 10
IS 1
A1 Yoshihiro Kanemitsu
A1 Ryota Kurokawa
A1 Taisuke Akamatsu
A1 Kensuke Fukumitsu
A1 Satoshi Fukuda
A1 Yutaka Ito
A1 Norihisa Takeda
A1 Hirono Nishiyama
A1 Keima Ito
A1 Tomoko Tajiri
A1 Yuta Mori
A1 Takehiro Uemura
A1 Hirotsugu Ohkubo
A1 Masaya Takemura
A1 Ken Maeno
A1 Tetsuya Oguri
A1 Toshihiro Shirai
A1 Akio Niimi
YR 2023
UL http://bmjopenrespres.bmj.com/content/10/1/e001283.abstract
AB Introduction Patients with chronic obstructive pulmonary disease (COPD) are often hospitalised due to severe acute exacerbation (AE) or community-acquired pneumonia (CAP). Previous studies revealed the association of cough reflex sensitivity with the pathophysiology of COPD and pneumonia. We hypothesised that cough reflex sensitivity may be associated with severe AE or CAP requiring hospitalisation in patients with COPD.Methods We prospectively recruited 68 patients with COPD between June 2018 and January 2020. Patient characteristics, lung and cardiac functions, and biomarkers, including capsaicin cough reflex sensitivity and blood eosinophil count, were evaluated at enrolment. All participants were monitored for AE or CAP requiring hospitalisation for 12 months. We determined the risk factors and ORs for hospitalisation in patients with COPD using a multivariate analysis.Results Eight patients experienced AE (n=3) or CAP (n=5) and required hospitalisation during follow-up. Patients in the hospitalisation+ group had higher modified Medical Research Council scores and blood eosinophil counts (≥300 µL) than those in the hospitalisation− group. Capsaicin cough reflex sensitivity tended to decrease in the hospitalisation+ group compared with that in the hospitalisation− group. Multivariate analysis revealed that a decreased capsaicin cough reflex and high eosinophil count (≥300 µL) were predictive risk factors for future hospitalisation due to AE-COPD or CAP.Conclusion In addition to eosinophils, decreased capsaicin cough reflex sensitivity was associated with hospitalisation due to AE-COPD or CAP. Capsaicin cough reflex sensitivity in patients with COPD may play a role in the prevention of severe AE or pneumonia requiring hospitalisation.Trial registration number UMIN000032497.Data are available upon reasonable request.