Extent of exposure to pirfenidone
| Integrated population (N=1299) | |
|---|---|
| Duration of treatment, years | |
| Median (range) | 1.7 (>0 to 9.9) |
| >0 to <1 | 404 (31.1%) |
| 1 to <2 | 350 (26.9%) |
| 2 to <3 | 118 (9.1%) |
| 3 to <4 | 102 (7.9%) |
| ≥4 | 325 (25.0%) |
| Person exposure years (PEY)* | 3160 |
| Daily dose, mg† | |
| Mean (SD) | 2053.8 (484.9) |
| Median (range) | 2270.4 (25–3600) |
| >0 to ≤1800 | 295 (22.7%) |
| >1800 to ≤2200 | 228 (17.6%) |
| >2200 to 2600 | 736 (56.7%) |
| >2600 | 19 (1.5%) |
| Missing | 21 (1.6%) |
*One PEY is the equivalent of one patient exposed to study drug for 1 year; total PEY is the sum of the PEY of each patient.
†Calculated over the total duration of use, excluding the 2-week titration period.