Characteristics and HRCT findings of patients with pulmonary Mycobacterium avium and M. intracellulare
| Pulmonary M. avium disease (n=208) | Pulmonary M. intracellulare disease (n=67) | p Value | |
|---|---|---|---|
| Age at diagnosis, years | 61.0±11.6 | 64.7±11.5 | 0.0029 |
| Gender (female) | 158 (76.0) | 47 (70.2) | 0.34 |
| Body mass index, kg/m2 | 19.6±2.6 | 18.7±3.2 | 0.012 |
| Smoking status (never) | 163 (78.4) | 56 (83.6) | 0.36 |
| Chronic microorganism co-infection | 87 (41.8) | 37 (55.2) | 0.055 |
| Intermittent microorganism co-infection | 27 (13.0) | 14 (20.9) | 0.11 |
| Underlying disease | |||
| Bronchiectasis | 177 (85.1) | 57 (85.1) | >0.99 |
| Severe pneumonia (hospitalisation) | 53 (25.5) | 28 (41.8) | 0.011 |
| COPD | 22 (10.6) | 6 (9.0) | 0.81 |
| Asthma | 19 (9.1) | 5 (7.5) | 0.81 |
| History of tuberculosis | 23 (11.1) | 11 (16.4) | 0.25 |
| History of malignant disease | 36 (17.3) | 21 (31.3) | 0.014 |
| Diabetes mellitus | 19 (9.1) | 7 (10.5) | 0.81 |
| Autoimmune disease | 22 (10.6) | 14 (20.9) | 0.029 |
| Rheumatoid arthritis | 11 (5.3) | 8 (11.9) | 0.092 |
| GORD symptom | 34 (16.4) | 10 (14.9) | 0.77 |
| Use of systemic corticosteroids | 12 (5.8) | 10 (14.9) | 0.016 |
| Use of immunosuppressant agent | 15 (7.2) | 9 (13.4) | 0.14 |
| Use of inhaled corticosteroids | 14 (6.7) | 5 (7.5) | 0.79 |
| Duration of MAC disease, years | 7.3±6.6 | 7.0±8.1 | 0.34 |
| HRCT findings | |||
| Nodule | 179 (86.1) | 58 (86.6) | >0.99 |
| Consolidation | 114 (54.8) | 38 (56.7) | 0.78 |
| Bronchiectasis | 177 (85.1) | 57 (85.1) | >0.99 |
| Cavity | 66 (31.7) | 32 (47.8) | 0.017 |
| Radiographic pattern | |||
| NB form | 125 (60.1) | 27 (40.3) | 0.0072 |
| FC form | 17 (8.2) | 8 (11.9) | 0.34 |
| NB+FC form | 48 (23.1) | 24 (35.8) | 0.039 |
| Unclassified | 18 (8.7) | 8 (11.9) | 0.47 |
| Thoracic abnormality | |||
| Scoliosis | 49 (23.6) | 23 (34.3) | 0.08 |
| Pectus excavatum | 25 (12.0) | 6 (9.0) | 0.66 |
| Location of HRCT findings | |||
| Right/left upper lobe | 157 (75.5) | 51 (76.1) | 0.92 |
| Right middle lobe/lingula | 189 (90.9) | 64 (95.5) | 0.3 |
| Right/left lower lobe | 135 (64.9) | 57 (85.1) | 0.0018 |
Data show either the number (%) of patients or the mean±SD.
COPD, chronic obstructive pulmonary disease; FC, fibrocavitary; GORD, gastro-oesophageal reflux disease; HRCT, high-resolution CT; MAC, M. avium complex; NB, nodular/bronchiectatic.