Lung vs matched tumour (±SD) | Squamous cell carcinoma vs adenocarinoma (±SD) | Emphysema vs histologically normal lung (±SD) | |||||||
---|---|---|---|---|---|---|---|---|---|
Lung | Tumour | Squamous | Adenocarcinoma | Emphysema | Normal | ||||
Measured kinase | n=19 | n=19 | p Value* | n=10 | n=9 | p Value† | n=13 | n=7 | p Value† |
Total ERK (RU) | 17 179±8222 | 18 578±9886 | 0.75 | 19 815±10 399 | 17 298±9099 | 0.65 | 18 836±8147 | 14 997±9638 | 0.51 |
Total ppERK (RU) | 2630±912 | 1170±355 | 0.006 | 1236±506 | 977±239 | 0.67 | 4159±1722 | 853±422 | 0.001 |
ppERK as per cent total ERK | 19.1±11.2 | 8.8±8.6 | 0.002 | 8.3±6.3 | 9.3±11.1 | 0.80 | 23.5±9.2 | 8.3±9.0 | 0.002 |
Total AKT (RU) | 6457±2673 | 25 645±10 447 | 0.0001 | 27 040±11 803 | 24 155±8750 | 0.79 | 7079±2748 | 6026±2780 | 0.70 |
Phospho-AKT (RU) | 1932±511 | 10 186±3327 | 0.001 | 9204±3020 | 11 402 ±3516 | 0.69 | 2223±557 | 1706±490 | 0.68 |
pAKT as per cent total AKT | 33.2±13.5 | 48.6±13.0 | 0.001 | 48.7±15.2 | 48.4±11.0 | 0.96 | 34.3±12.7 | 31.7±14.9 | 0.69 |
*Paired t test.
†Student t test.
pp, doubly phosphorylated.