Table 1

Characteristics of healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP)

Healthy controlIPFHPp Value
Subjects (n)291426
Age (years)25.9±7.5168.1±1.761.7±2.51p<0.001
 Female12 (41.4)6 (42.9)11 (42.3)NS
 Male17 (58.6)8 (57.1)15 (57.7)NS
Smoker07 (50.0)9 (34.6)
Type of disease onset
 AcuteND07 (26.9)
 Non-acuteND14 (100)19 (73.1)
VC (% pred)ND74.9±6.9882.0±4.90NS
FEV1 (% pred)ND82.7±1.4379.3±3.73NS
TLC (% pred)ND71.9±6.8967.7±12.7NS
DLco (% pred)ND66.8±6.0267.9±6.60NS
Total cell counts (104/mm2)6.64±5.79.39±1.8428.5±5.54p<0.001
Differential cell count
 Macrophage (%)87.5±15.178.1±5.4743.8±4.26p<0.001
 Lymphocyte (%)7.19±4.9617.5±5.5352.5±1.83p<0.001
 Neutrophil (%)0.74±0.802.58±0.392.06±0.41NS
 Eosinophil (%)0.24±0.362.19±0.091.34±0.63NS
CD4/8 ratioND1.87±0.062.22±0.40NS
  • Data are shown as means±SDs. Brackets indicate percentages.

  • p Values were calculated by comparing patients with HP with healthy volunteers and patients with IPF by using Tukey's test.

  • DLco, diffusing capacity of the lungs for carbon monoxide; FEV1, forced expiratory volume in 1 s; ND, not determined; NS, no statistical significance; TLC, total lung capacity; VC, vital capacity.