Characteristics of the patients at baseline and surgical data*
| Characteristics | Oxygenated blood (N=29) | HTK solution (N=29) | No pulmonary perfusion (N=31) |
|---|---|---|---|
| Demographic characteristics | |||
| Age—year | 69.9±10.8 | 69.6±8.0 | 70.5±8.9 |
| Male sex—number (%) | 22 (75.9) | 20 (69.0) | 25 (80.6) |
| Comorbidities—number/total number (%) (number of patients with missing values) | |||
| Self-reported COPD | 15/29 (51.7) | 18/29 (62.1) | 19/31 (61.3) |
| Pulmonary hypertension determined by preoperative echocardiographic | 3/29 (10.3) (5) | 7/29 (24.1) (3) | 6/31 (19.4) (8) |
| Arterial hypertension | 23/29 (79.3) | 24/29 (82.8) | 22/31 (71.0) |
| Chronic atrial fibrillation or flutter | 4/29 (13.8) | 3/29 (10,3) [1] | 5/31 (16.1) |
| Chronic heart failure † | 13/29 (44.8) | 6/29 (20.7) [2] | 9/31 (29.0) |
| ASA class IV or worse | 1/29 (3.4) | 4/29 (13.8) [2] | 4/31 (12.9) [2] |
| Median left ventricular ejection fraction (IQR) | 52.5 (41.2–60.0) [1] | 50.0 (37.5–60.0) | 55.0 (45.0–60.0) |
| Recent AMI‡ | 7/29 (24.1) | 11/29 (37.9) | 7/31 (22.6) |
| Insulin-dependent diabetes mellitus | 3/29 (10.3) | 3/29 (10.3) | 2/31 (6.5) |
| Median estimated creatinine clearance (IQR) § | 82.5 (64.2–121.9) | 82.7 (62.8–107.3) | 86.1 (65.2–106.8) |
| Previous transit ischaemic attack or stroke | 1/29 (3.4) | 7/29 (24.1) | 7/31 (22.6) |
| Previous percutaneous coronary intervention | 11/29 (37.9) | 7/29 (24.1) | 7/31 (22.6) |
| Implantable cardioverter defibrillator or pacemaker | 2/29 (6.9) [2] | 1/29 (3.4) [1] | 1/31 (3.2) [1] |
| Greater alcohol consumption¶ | 11/29 (37.9) | 7/29 (24.1) | 7/31 (22.6) |
| Median tobacco pack years (IQR) | 40.0 (18.5–51.0) | 45.0 (32.5–50.0) | 35.0 (20.0–45.0) |
| Pulmonary function | |||
| Median per cent predicted forced expiratory volume in 1 s. (IQR) | 75.0 (56.5–87.5) | 79.0 (58.5–88.0) | 74.0 (58.0–88.0) |
| GOLD classification Mild | 14/29 (48.3) | 14/29 (48.3) | 12/31 (38.7) |
| GOLD classification Moderate | 11/29 (37.9) | 14/29 (48.3) | 17/29 (54.8) |
| GOLD classification Severe | 3/29 (10.3) | 1/29 (3.4) | 2/31 (6.5) |
| GOLD classification Very severe | 1/29 (3.5) | 0/29 (0.0) | 0/29 (0.0) |
| Surgical data | |||
| Elective surgery | 18/29 (62.1) | 16/29 (55.2) | 23/31 (74.2) |
| Urgent surgery | 11/29 (37.9) | 13/29 (44.8) | 8/31 (25.8) |
| Type of surgery | |||
| AVR | 7/29 (24.1) | 7/29 (24.1) | 12/31 (38.7) |
| CABG | 15/29 (51.7) | 17/29 (58.6) | 17/31 (54.8) |
| CABG and AVR | 7/29 (24.1) | 5/29 (17.2) | 2/31 (6.5) |
| Cardiopulmonary bypass time (min) | 102.2±53.7 | 100.9±26.5 | 98.45±44.6 |
| Aortic cross-clamp time (min) | 58.8±37.9 | 64.3±18.3 | 61.9±34.7 |
*Plus–minus values are means±SD. There were no statistical significant differences between the three groups for any of the variables.
†Chronic heart failure was defined as New York Heart Association Class III or worse.
‡Recent AMI is within 3 months prior to the surgery.
§Estimated creatinine clearance by Cockcroft-Gault equation in mL/min/1.73 m2.
¶Greater alcohol consumption was defined as >14 for women and >21 for men units' alcohol per week.
AMI, acute myocardial infarction; ASA, American Society of Anesthesiologists; AVR, aortic valve replacement; CABG, coronary artery bypass graft; COPD, chronic obstructive pulmonary disease; GOLD, global initiative for chronic obstructive lung disease; HTK, histidine-tryptophan-ketoglutarate.