Table 2

Direct, indirect and total standardised effects of Groups 1–3×age interaction (model 1) and of physical exercise (model 2) on outcomes reflecting the different aspects of the variable psychological well-being, mediated by medical status

		Model 1				Model 2
Outcome	Effect	Medical status	Groups 1–3	Age	Groups 1–3×Age	Medical status	Exercise
Med. Stat.	Direct	–	−0.22 (0.12)†	0.06 (0.13)†	−0.60 (0.18)†**	–	0.39 (0.13)†*
Psychologicalwell-being‡	Direct	0.42 (0.18)*	0.09 (0.13)	0.15 (0.16)	0.07 (0.17)	0.44 (0.16)*	−0.13 (0.14)
	Indirect§	–	−0.09 (0.06)	0.03 (0.05)	−0.25 (0.11)*	–	0.17 (0.10)
	Total	0.42 (0.18)*	−0.00 (0.13)	0.18 (0.16)	−0.18 (0.16)	0.44 (0.16)*	0.04 (0.10)
CFQ-R Total	Direct	0.75 (0.13)**	0.07 (0.13)	0.37 (0.14)*	0.04 (0.17)	0.77 (0.14)**	−0.10 (0.11)
	Indirect§	–	−0.14 (0.11)	0.04 (0.09)	−0.42 (0.16)*	–	0.30 (0.13)*
	Total	0.75 (0.13)**	−0.07 (0.13)	0.41 (0.15)*	−0.38 (0.15)*	0.77 (0.14)**	0.20 (0.08)*
HADS-Anxiety	Direct	0.10 (0.19)	0.13 (0.12)	0.17 (0.17)	−0.11 (0.19)	0.14 (0.19)	0.06 (0.12)
	Indirect§	–	−0.03 (0.05)	0.01 (0.02)	−0.06 (0.12)	–	0.05 (0.07)
	Total	0.10 (0.19)	0.10 (0.11)	0.18 (0.16)	−0.18 (0.15)	0.14 (0.19)	0.11 (0.10)
HADS-Depression	Direct	−0.43 (0.21)*	−0.25 (0.13)	−0.19 (0.18)	0.00 (0.19)	−0.46 (0.18)*	0.16 (0.17)
	Indirect§	–	0.09 (0.06)	−0.02 (0.06)	0.25 (0.12)*	–	−0.18 (0.11)
	Total	−0.43 (0.21)*	−0.16 (0.13)	−0.22 (0.17)	0.25 (0.17)	−0.46 (0.18)*	−0.02 (0.12)

*p<0.05; ** p<0.001; Note: In model 1, the effects are adjusted for the patients' sex, partner status and educational level. In model 2, the effects are also adjusted for age and cftr gene mutation class.
‡The mean of standardised CFQ-R Total, HADS-Anxiety (reversed) and HADS-Depression (reversed).
§Via medical status.
†With psychological well-being as outcome.
CFQ-R, Cystic Fibrosis Questionnaire-Revised; HADS A and D, Hospital Anxiety and Depression Scale Anxiety and Depression.