Patients with CAP and low levels of serum immunoglobulins according to the site of care
| Low levels of serum immunoglobulins, mg/dL (cutpoints) | Site of care of patients with CAP | p Value three study groups | p Value ICU vs non-ICU groups | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|
| Ambulatory (n=54) | Hospital ward (n=173) | ICU (n=191) | Non-ICU (n=227) | ||||
| IgG, total (≤680) | 7 (13) | 33 (19.1) | 75 (39.3) | 40 (17.6) | <0.001 | <0.001 | 3.03 (1.94 to 4.75) |
| IgG1 (≤323) | 3 (5.6) | 13 (7.5) | 41 (21.5) | 16 (7.1) | <0.001 | <0.001 | 3.59 (1.94 to 6.63) |
| IgG2 (≤154) | 8 (14.8) | 31 (17.9) | 52 (27.2) | 39 (17.2) | <0.04 | <0.013 | 1.8 (1.13 to 2.89) |
| IgG3 (≤10) | 1 (1.9) | 0 | 5 (2.6) | 1 (0.4) | 0.108 | 0.098 | 6.05 (0.7 to 52.2) |
| IgG4 (≤5) | 3 (5.6) | 7 (4.0) | 5 (2.6) | 10 (4.4) | 0.544 | 0.328 | 0.58 (0.2 to 1.74) |
| IgA (≤50) | 1 (2.0) | 4 (2.3) | 7 (3.7) | 5 (2.2) | 0.683 | 0.389 | 1.60 (0.81 to 3.17) |
| IgM (≤30) | 3 (5.6) | 13 (7.5) | 21 (11.0) | 16 (7.1) | 0.366 | 0.173 | 1.66 (0.52 to 5.32) |
Data as frequencies and percentages in parentheses.
CAP, community-acquired pneumonia; ICU, intensive care unit.