Table 3

Risk factors associated with mortality in patients with pulmonary aspergillosis

Dead, n=14Alive, n=55p Value
Age (years)
 <352 (14.3)18 (32.7)0.31
 35–453 (21.4)13 (23.6)
 >459 (64.3)24 (43.6)
Gender
 Male8 (57.1)40 (72.7)0.25
 Female6 (42.9)15 (27.3)
Smoking status
 Current2 (16.7)00.004
 Ex-smoker1 (8.3)18 (34.6)
 Non-smoker9 (75)34 (65.4)
Renal failure8 (57.14)8 (14.54)0.002
DM8 (57.1)14 (25.5)0.05
Steroids use3 (21.4)12 (21.8)0.64
Chemotherapy2 (14.28)3 (5.4)0.26
Haematological malignancies5 (35.7)5 (9.1)0.01
Past TB2 (14.2)25 (45.45)0.22
Active TB2 (14.2)7 (12.7)0.58
COPD07 (12.7)0.18
Asthma2 (14.28)5 (9.09)0.43
Nodular infiltrates9 (64.28)20 (36.36)0.29
Consolidation11 (78.57)8 (14.54)0.001
Bronchiectasis1 (7.14)9 (16.36)0.24
Fungal ball3 (21.4)22 (40.0)0.11
Respiratory complications11 (78.6)17 (30.9)0.002
Length of hospital stay (mean days)16.2±10.49.1±8.20.009
Pneumothorax3 (21.4%)7 (12.72%)0.32
ICU stay13 (92.85%)5 (9.09%)0.001
Mechanical ventilation14 (100%)3 (5.45%)0.001
NIMV use1 (7.14%)7 (12.72%)0.48
Surgical resection1 (7.1)27 (49.1)0.001
Independent factors associated with mortality on multivariate analysis
FactorsOR ( 95% CI)p Value
Hypoxic respiratory failure6.80 (1.46 to 31.60)0.01
DM6.91 (1.46 to 32.54)0.01
Length of hospital stay (mean days)1.08 (1.007 to 1.15)0.03
  • DM, diabetes mellitus; ICU, intensive care unit; NIMV, non-invasive mechanical ventilation; TB, tuberculosis.