The effect of β-blockade on change in lung function, dynamic hyperinflation and peak exercise according to whether the individual had chronic obstructive pulmonary disease
| Change; non-COPD (n=23) | Change; COPD (n=15) | p Value | |
|---|---|---|---|
| FEV1 (L) | −0.09 (0.32) | −0.11 (0.18) | 0.76 |
| FEV1 (% predicted) | −1.9 (5.9) | −4.2 (6.5) | 0.24 |
| FVC (L) | 0.01 (0.35) | −0.09 (0.29) | 0.30 |
| FVC (% predicted) | 0.2 (5.7) | −2.2 (8.3) | 0.32 |
| FEV1/FVC | −0.01 (0.06) | −0.02 (0.06) | 0.49 |
| RV/TLC (% predicted) | −2.1 (3.5) | 0.5 (5.1) | 0.27 |
| Raw (kPa/s/L) | −0.15 (0.66) | −0.13 (0.84) | 0.90 |
| sGaw (kPa/s) | 0.01 (0.05) | 0 (0.01) | 0.78 |
| sRaw (kPa/s) | 0.74 (1.89) | 1.17 (1.87) | 0.5 |
| IC (L) at rest | 0 (1.10) | −0.05 (0.62) | 0.46 |
| VO2 at LT (mL/min) | −0.21 (1.34) | −0.54 (1.40) | 0.54 |
| VO2 at peak (mL/min) | 0.11 (2.31) | 0.21 (2.11) | 0.90 |
| Oxygen pulse (mL/beat) | −1.52 (2.23) | −2.17 (2.09) | 0.42 |
| VE/VO2 | 0.97 (3.90) | 0.48 (3.63) | 0.70 |
| VE/VCO2 | 1.27 (2.33) | 0.23 (1.72) | 0.45 |
| Workload (W) | −1.1 (7.7) | 4.3 (9.5) | 0.08 |
| Heart rate (bpm) | −17 (11) | −17 (7) | 0.60 |
| Change in IC (L)—dynamic hyperinflation | 0.02 (0.24) | −0.07 (0.30) | 0.09 |
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; IC, inspiratory capacity; LT, lactate threshold; Raw, airway resistance; RV, residual volume; sGaw, specific airway conductance; sRaw, specific airway resistance; TLC, total lung capacity; VCO2, maximal carbon dioxide output; VE, minute ventilation; VO2, maximal oxygen uptake.